All Phenotypes Adcy7<tm1.1Pcst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adcy7^tm1.1Pcst
targeted mutation 1.1, Paul C Sternweis
MGI:5470143

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adcy7^tm1.1Pcst/Adcy7^tm1.1Pcst Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:5470146

Allelic Composition	Adcy7^tm1.1Pcst/Adcy7^tm1.1Pcst Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy7^tm1.1Pcst mutation (0 available); any Adcy7 mutation (59 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

peritoneal inflammation ( J:191067 )

• in a zymosan induced peritonitis model, mice exhibit prolonged inflammation compared with control mice

• however, bone marrow-derived macrophage phagocytosis of zymosan is normal

increased tumor necrosis factor secretion ( J:191067 )

• from bone marrow-derived macrophages in response to zymosan

digestive/alimentary system

peritoneal inflammation ( J:191067 )

• in a zymosan induced peritonitis model, mice exhibit prolonged inflammation compared with control mice

• however, bone marrow-derived macrophage phagocytosis of zymosan is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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