About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbfbtm5Ppl
targeted mutation 5, Pu P Liu
MGI:5469976
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cbfbtm5Ppl/Cbfbtm5Ppl Not Specified MGI:5470055
ht2
 		Cbfbtm5Ppl/Cbfb+ Not Specified MGI:5470056


Genotype
MGI:5470055
hm1
Allelic
Composition		 Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm5Ppl mutation (0 available); any Cbfb mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
impaired hematopoiesis ( J:193140 )
• one line exhibited increased immature hematopoietic progenitors and decreased mature hematopoietic progenitors compared with wild-type mice
• at E12.5, mice exhibit a block in definite hematopoiesis

cardiovascular system
intracranial hemorrhage ( J:193140 )
• in the central nervous system

nervous system
intracranial hemorrhage ( J:193140 )
• in the central nervous system




Genotype
MGI:5470056
ht2
Allelic
Composition		 Cbfbtm5Ppl/Cbfb+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm5Ppl mutation (0 available); any Cbfb mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mononuclear cell differentiation ( J:193140 )
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
myeloid hyperplasia ( J:193140 )
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice

neoplasm
neoplasm ( J:193140 )
N
• ENU-treated mice do not develop leukemia

cellular
abnormal mononuclear cell differentiation ( J:193140 )
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

immune system
abnormal mononuclear cell differentiation ( J:193140 )
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
myeloid hyperplasia ( J:193140 )
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory