Phenotypes associated with this allele

• Allele Symbol: Pycard^tm1Ayaz
• Allele Name: targeted mutation 1, Amir S Yazdi
• Allele ID: MGI:5467340
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pycard^tm1Ayaz/Pycard^tm1Ayaz Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5467385
cn2	Pycard^tm1Ayaz/Pycard^tm1Ayaz Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5467386

Genotype
MGI:5467385

cn1

• Allelic Composition: Pycard^tm1Ayaz/Pycard^tm1Ayaz; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 alpha secretion ( J:191239 )

• from tumors induced by DMBA

decreased interleukin-1 beta secretion ( J:191239 )

• from tumors induced by DMBA

decreased interleukin-6 secretion ( J:191239 )

• from tumors induced by DMBA

decreased tumor necrosis factor secretion ( J:191239 )

• from tumors induced by DMBA

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit fewer tumors with a later onset compared with type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit fewer tumors with a later onset compared with type mice

Genotype
MGI:5467386

cn2

• Allelic Composition: Pycard^tm1Ayaz/Pycard^tm1Ayaz; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

neoplasm

neoplasm ( J:191239 )

N • mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit normal skin tumor formation