Phenotypes associated with this allele

• Allele Symbol: Mefv^tm1Bhk
• Allele Name: targeted mutation 1, Beverly H Koller
• Allele ID: MGI:5465109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mefv^tm1Bhk/Mefv^tm1Bhk	129S6/SvEvTac-Mefv^tm1Bhk	MGI:5465121

Genotype
MGI:5465121

hm1

• Allelic Composition: Mefv^tm1Bhk/Mefv^tm1Bhk
• Genetic Background: 129S6/SvEvTac-Mefv^tm1Bhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:192443 )

N • mice exhibit normal response to LPS

N • macrophages from LPS exposed mice produce normal levels of IL6 and lactate dehydrogenase in response to titanium dioxide with or without muramyl dipeptide, aluminum hydroxide, calcium pyrophosphate dehydrate, adenosine 5' triphosphate or flagellin or lethal toxin of Bacillus anthracis

increased interleukin-1 beta secretion ( J:192443 )

• from macrophages from LPS exposed mice stimulated with titanium dioxide with or without muramyl dipeptide, aluminum hydroxide, calcium pyrophosphate dehydrate, adenosine 5' triphosphate or flagellin or lethal toxin of Bacillus anthracis

increased interleukin-18 secretion ( J:192443 )

• from macrophages exposed to LPS stimulated with titanium dioxide with or without muramyl dipeptide