Mouse Genome Informatics
cx1
     Tg(SOD1)2Gur/0
Tg(SOD1*A4V)A1073Gur/0
involves: C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
premature death ( J:109458 )
• lifespan is on average 318.5 days

nervous system
abnormal spinal cord grey matter morphology ( J:109458 )
• mutants exhibit protein aggregates in spinal cords
abnormal nervous system physiology ( J:109458 )
• mutants develop an amyotrophic lateral sclerosis-like phenotype, with an average onset of disease at 227.4 days

Mouse Models of Human Disease
 OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109458


Mouse Genome Informatics
tg2
     Tg(SOD1*A4V)A1073Gur/0
involves: C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:32665 , J:109458 )
• mice appear normal and do not develop motor neuron disease (J:32665)