• mean age of death is 126 +/- 16 days, earlier than in hemizygous mice

• phenotype is stated to be identical to hemizygous mice, however no data are presented

• phenotype is stated to be identical to hemizygous mice, however no data are presented

• reactive gliosis in the spinal cord, predominantly in the lower spinal cord

• eosinophilic cytoplasmic inclusions are seen in the motor neurons that remain; inclusions resemble Lewy body-like hyaline inclusions, with the halo of inclusions composed of neurofilamentous structure and the core of granule-associated fibrils

• mean age of onset of motor neuron disease symptoms is 120 +/- 14 days, earlier than in hemizygotes

• loss of anterior horn cells in the spinal cord, predominantly in the lower spinal cord

• mean age of onset of disease symptoms is 120 +/- 14 days, earlier than in hemizygotes

• phenotype is stated to be identical to hemizygous mice, however no data are presented

• phenotype is stated to be identical to hemizygous mice, however no data are presented

• mean age of death is 372 +/- 78 days

• mutants first show signs of hindlimb paraparesis and relatively symmetrical forelimb weakness (hemiparesis)

• reactive gliosis in the spinal cord, predominantly in the lower spinal cord

• eosinophilic cytoplasmic inclusions are seen in the motor neurons that remain; inclusions resemble Lewy body-like hyaline inclusions, with the halo of inclusions composed of neurofilamentous structure and the core of granule-associated fibrils

• mean age of onset of motor neuron disease symptoms is 337 +/- 101 days

• loss of anterior horn cells in the spinal cord, predominantly in the lower spinal cord

• muscle atrophy is seen at the end stage of disease

• some mutants exhibit muscle cramps after exercise as a first symptom of disease