About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*)DF7Yaw
transgene insertion DF7, Yasuhiro Watanabe
MGI:5449420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SOD1*)DF7Yaw/Tg(SOD1*)DF7Yaw C57BL/6-Tg(SOD1*)DF7Yaw MGI:5449422
tg2
Tg(SOD1*)DF7Yaw/0 C57BL/6-Tg(SOD1*)DF7Yaw MGI:5449421


Genotype
MGI:5449422
tg1
Allelic
Composition
Tg(SOD1*)DF7Yaw/Tg(SOD1*)DF7Yaw
Genetic
Background
C57BL/6-Tg(SOD1*)DF7Yaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean age of death is 126 +/- 16 days, earlier than in hemizygous mice

behavior/neurological
• phenotype is stated to be identical to hemizygous mice, however no data are presented
• phenotype is stated to be identical to hemizygous mice, however no data are presented

nervous system
• reactive gliosis in the spinal cord, predominantly in the lower spinal cord
• eosinophilic cytoplasmic inclusions are seen in the motor neurons that remain; inclusions resemble Lewy body-like hyaline inclusions, with the halo of inclusions composed of neurofilamentous structure and the core of granule-associated fibrils
• mean age of onset of motor neuron disease symptoms is 120 +/- 14 days, earlier than in hemizygotes
• loss of anterior horn cells in the spinal cord, predominantly in the lower spinal cord

muscle
• mean age of onset of disease symptoms is 120 +/- 14 days, earlier than in hemizygotes
• phenotype is stated to be identical to hemizygous mice, however no data are presented

skeleton
• phenotype is stated to be identical to hemizygous mice, however no data are presented

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:97932




Genotype
MGI:5449421
tg2
Allelic
Composition
Tg(SOD1*)DF7Yaw/0
Genetic
Background
C57BL/6-Tg(SOD1*)DF7Yaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean age of death is 372 +/- 78 days

behavior/neurological
• mutants first show signs of hindlimb paraparesis and relatively symmetrical forelimb weakness (hemiparesis)

nervous system
• reactive gliosis in the spinal cord, predominantly in the lower spinal cord
• eosinophilic cytoplasmic inclusions are seen in the motor neurons that remain; inclusions resemble Lewy body-like hyaline inclusions, with the halo of inclusions composed of neurofilamentous structure and the core of granule-associated fibrils
• mean age of onset of motor neuron disease symptoms is 337 +/- 101 days
• loss of anterior horn cells in the spinal cord, predominantly in the lower spinal cord

muscle
• muscle atrophy is seen at the end stage of disease
• some mutants exhibit muscle cramps after exercise as a first symptom of disease

skeleton

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:97932





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory