Phenotypes associated with this allele

• Allele Symbol: Kdm6a^tm1.2Kaig
• Allele Name: targeted mutation 1.2, Kai Ge
• Allele ID: MGI:5448825
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6a^tm1.2Kaig/Kdm6a^tm1.2Kaig	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5448830
ot2	Kdm6a^tm1.2Kaig/Y	involves: 129S4/SvJaeSor	MGI:5448831

Genotype
MGI:5448830

hm1

• Allelic Composition: Kdm6a^tm1.2Kaig/Kdm6a^tm1.2Kaig
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Neural tube closure, cardiac development and hematopoiesis defects in Kdm6a^tm1.2Kaig/Kdm6a^tm1.2Kaig females

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:190157 )

♀ • mice do not survive beyond E10.5

embryo

abnormal rostral-caudal axis patterning ( J:190157 )

♀ • abnormal or truncated posterior bodies

caudal body truncation ( J:190157 )

♀

abnormal neural tube closure ( J:190157 )

♀ • severe defects

abnormal notochord morphology ( J:190157 )

♀ • defective posterior notochord formation

cardiovascular system

abnormal heart development ( J:190157 )

♀ • severe defects

hematopoietic system

anemia ( J:190157 )

♀ • at E10.5

nervous system

abnormal neural tube closure ( J:190157 )

♀ • severe defects

Genotype
MGI:5448831

ot2

• Allelic Composition: Kdm6a^tm1.2Kaig/Y
• Genetic Background: involves: 129S4/SvJaeSor

Execenphaly in Kdm6a^tm1.2Kaig/Y males

mortality/aging

perinatal lethality, complete penetrance ( J:190157 )

♂ • mice die around birth

embryo

embryo phenotype ( J:190157 )

♂N • mice exhibit normal mesoderm development

abnormal neural tube closure ( J:190157 )

♂

respiratory system

atelectasis ( J:190157 )

♂ • lungs are not inflated at birth

respiratory distress ( J:190157 )

♂ • inability to breath

nervous system

abnormal neural tube closure ( J:190157 )

♂

exencephaly ( J:190157 )

♂ • in some mice