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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(BCL2/IGH)#Jcre
transgene insertion, John C Reed
MGI:5447039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0
involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J MGI:5447049


Genotype
MGI:5447049
cx1
Allelic
Composition
Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0
Genetic
Background
involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die by 6 months (J:94116)
• by 14 months, less than 20% of mice are alive (J:94116)
• some mice die by 6 months (J:94116)
• by 14 months, less than 20% of mice are alive (J:94116)

immune system
• resistant to spontaneous and drug-induced apoptosis (J:94116)
• resistant to spontaneous and drug-induced apoptosis (J:94116)
• in the blood of mice that develop leukemia (J:94116)
• in the blood of mice that develop leukemia (J:94116)
• in three-quarters of mice in nodal and extranodal location (J:94116)
• in three-quarters of mice in nodal and extranodal location (J:94116)
• in one-quarter of mice in nodal and extranodal location (J:94116)
• in one-quarter of mice in nodal and extranodal location (J:94116)
• detected at birth (J:94116)
• severe at death (J:94116)
• detected at birth (J:94116)
• severe at death (J:94116)
• 2-fold at 10 to 16 months (J:94116)
• 10 times at death (J:94116)
• 2-fold at 10 to 16 months (J:94116)
• 10 times at death (J:94116)
• expanded due to infiltration of small B lymphocytes (J:94116)
• expanded due to infiltration of small B lymphocytes (J:94116)
• small B lymphocytes infiltrate the marginal zone (J:94116)
• small B lymphocytes infiltrate the marginal zone (J:94116)

tumorigenesis
• small B cell lymphoma with expansion of different clones (J:94116)
• small B cell lymphoma with expansion of different clones (J:94116)

respiratory system
• common (J:94116)
• common (J:94116)

homeostasis/metabolism
• in half of mice (J:94116)
• in half of mice (J:94116)
• common (J:94116)
• common (J:94116)

cellular
• resistant to spontaneous and drug-induced apoptosis (J:94116)
• resistant to spontaneous and drug-induced apoptosis (J:94116)

hematopoietic system
• resistant to spontaneous and drug-induced apoptosis (J:94116)
• resistant to spontaneous and drug-induced apoptosis (J:94116)
• in the blood of mice that develop leukemia (J:94116)
• in the blood of mice that develop leukemia (J:94116)
• in three-quarters of mice in nodal and extranodal location (J:94116)
• in three-quarters of mice in nodal and extranodal location (J:94116)
• in one-quarter of mice in nodal and extranodal location (J:94116)
• in one-quarter of mice in nodal and extranodal location (J:94116)
• detected at birth (J:94116)
• severe at death (J:94116)
• detected at birth (J:94116)
• severe at death (J:94116)
• 2-fold at 10 to 16 months (J:94116)
• 10 times at death (J:94116)
• 2-fold at 10 to 16 months (J:94116)
• 10 times at death (J:94116)
• expanded due to infiltration of small B lymphocytes (J:94116)
• expanded due to infiltration of small B lymphocytes (J:94116)
• small B lymphocytes infiltrate the marginal zone (J:94116)
• small B lymphocytes infiltrate the marginal zone (J:94116)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Lymphocytic; CLL 151400 J:94116





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory