Mouse Genome Informatics
cx1
    Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0

involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• some mice die by 6 months
• by 14 months, less than 20% of mice are alive

immune system
• resistant to spontaneous and drug-induced apoptosis
• in the blood of mice that develop leukemia
• in three-quarters of mice in nodal and extranodal location
• in one-quarter of mice in nodal and extranodal location
• detected at birth
• severe at death
• 2-fold at 10 to 16 months
• 10 times at death
• expanded due to infiltration of small B lymphocytes
• small B lymphocytes infiltrate the marginal zone

tumorigenesis
• small B cell lymphoma with expansion of different clones

respiratory system
• common

homeostasis/metabolism
• in half of mice
• common

cellular
• resistant to spontaneous and drug-induced apoptosis

hematopoietic system
• resistant to spontaneous and drug-induced apoptosis
• in the blood of mice that develop leukemia
• in three-quarters of mice in nodal and extranodal location
• in one-quarter of mice in nodal and extranodal location
• detected at birth
• severe at death
• 2-fold at 10 to 16 months
• 10 times at death
• expanded due to infiltration of small B lymphocytes
• small B lymphocytes infiltrate the marginal zone

Mouse Models of Human Disease
OMIM IDRef(s)
Leukemia, Chronic Lymphocytic; CLL 151400 J:94116