Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b2tm2Mom mutation
(2 available);
any
Gucy1b2 mutation
(33 available)
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nervous system
N |
• homozygotes have a normal hyperventilation response to a 10% oxygen environment indicative of normal carotid body responses, despite the failure of type B olfactory sensory neurons to respond to hypoxia
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taste/olfaction
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• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl
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behavior/neurological
N |
• despite the failures of type B olfactory sensory neurons, homozygotes perform normally in a Morris water maze assay for place learning, spatial memory, and spatial navigation
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• in a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen
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homeostasis/metabolism
nervous system
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• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl
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respiratory system
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• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl
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