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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rspo3tm1.1Jcob
targeted mutation 1.1, John Cobb
MGI:5443941
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rspo3tm1.1Jcob/Rspo3tm1.1Jcob involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL MGI:5443987
cn2
Rspo3tm1.1Jcob/Rspo3tm1.2Jcob
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL MGI:5443989
cn3
Rspo2ftls/Rspo2ftls
Rspo3tm1.1Jcob/Rspo3tm1.2Jcob
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL MGI:5443990


Genotype
MGI:5443987
hm1
Allelic
Composition
Rspo3tm1.1Jcob/Rspo3tm1.1Jcob
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo3tm1.1Jcob mutation (1 available); any Rspo3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile with no obvious abnormalities




Genotype
MGI:5443989
cn2
Allelic
Composition
Rspo3tm1.1Jcob/Rspo3tm1.2Jcob
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo3tm1.1Jcob mutation (1 available); any Rspo3 mutation (14 available)
Rspo3tm1.2Jcob mutation (0 available); any Rspo3 mutation (14 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Rspo2ftls/Rspo2ftls Rspo3tm1.1Jcob/Rspo3tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

limbs/digits/tail
• slight in newborns
• however, adult mice exhibit normal limb length




Genotype
MGI:5443990
cn3
Allelic
Composition
Rspo2ftls/Rspo2ftls
Rspo3tm1.1Jcob/Rspo3tm1.2Jcob
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2ftls mutation (0 available); any Rspo2 mutation (19 available)
Rspo3tm1.1Jcob mutation (1 available); any Rspo3 mutation (14 available)
Rspo3tm1.2Jcob mutation (0 available); any Rspo3 mutation (14 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Rspo2ftls/Rspo2ftls Rspo3tm1.1Jcob/Rspo3tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

mortality/aging
• mice die at birth as do Rspo2ftls homozygotes

limbs/digits/tail
• in the forelimb
• in digits of the forelimbs in 5 of 6 mice; all mice lack 1 digit
• three shortened middle digits
• more subtle than in hindlimbs
• at birth, mice lack most of their hindlimbs
• hindlimb abnormalities are more severe more proximally than in Rspo2ftls homozygotes
• severely shortened and bent in two mice
• severely shortened in two mice
• in one mouse

respiratory system
• as in Rspo2ftls homozygotes

behavior/neurological
• as in Rspo2ftls homozygotes

skeleton
• severely shortened and bent in two mice
• severely shortened in two mice
• in one mouse





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory