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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdcp1tm1.2Moas
targeted mutation 1.2, Mark Moasser
MGI:5442763
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdcp1tm1.2Moas/Cdcp1tm1.2Moas B6.129-Cdcp1tm1.2Moas MGI:5442765
hm2
 		Cdcp1tm1.2Moas/Cdcp1tm1.2Moas involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478600
cn3
 		Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0 		involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL MGI:5478604
cx4
 		Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Tg(MMTV-PyVT)634Mul/0 		involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478601
cx5
 		Cdcp1tm1.2Moas/Cdcp1+
Tg(MMTV-PyVT)634Mul/0 		involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478603


Genotype
MGI:5442765
hm1
Allelic
Composition		 Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Genetic
Background		 B6.129-Cdcp1tm1.2Moas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:188990 )
• mice are viable and fertile




Genotype
MGI:5478600
hm2
Allelic
Composition		 Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194368 )
• mice did not exhibit gross morphologic or behavioral abnormalities




Genotype
MGI:5478604
cn3
Allelic
Composition		 Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194368 )
• euthanized 12 weeks after tamoxifen-treatment

integument
focal hair loss ( J:194368 )
• in tamoxifen-treated mice, particularly evident on the abdominal skin
abnormal skin morphology ( J:194368 )
• tamoxifen-treated mice develop more severe epidermal disease (thick skin, hair loss and scaling) compared with control mice
thick epidermis ( J:194368 )
• 3.5-fold in tamoxifen-treated mice than in control mice
abnormal skin condition ( J:194368 )
• in tamoxifen-treated mice, particularly evident on the abdominal skin
thick skin ( J:194368 )
• in tamoxifen-treated mice

neoplasm
increased tumor growth/size ( J:194368 )
• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
increased tumor incidence ( J:194368 )
• accelerated neoplasm development in tamoxifen-treated mice compared with control mice

behavior/neurological
hunched posture ( J:194368 )
• in tamoxifen-treated mice




Genotype
MGI:5478601
cx4
Allelic
Composition		 Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:194368 )
• mice are euthanized at 12 weeks due to numerous large tumors

neoplasm
increased tumor growth/size ( J:194368 )
• accelerated tumorigenesis compared with Tg(MMTV-PyVT)634Mul mice
increased tumor incidence ( J:194368 )
• at 12 weeks mice exhibit a 2.6-fold increase in the number of tumors per mouse with an average of 5.7-fold increase in total tumor burden compared with Tg(MMTV-PyVT)634Mul mice
• with lung metastases




Genotype
MGI:5478603
cx5
Allelic
Composition		 Cdcp1tm1.2Moas/Cdcp1+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:194368 )
• slight compared with Tg(MMTV-PyVT)634Mul mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory