About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zfp36tm1.1Xen
targeted mutation 1.1, Taconic Biosciences
MGI:5441582
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Zfp36tm1.1Xen/Zfp36tm1.1Xen
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N MGI:5441587


Genotype
MGI:5441587
cn1
Allelic
Composition
Zfp36tm1.1Xen/Zfp36tm1.1Xen
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
Zfp36tm1.1Xen mutation (0 available); any Zfp36 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mild inflammation and fibrosis in 3 of 4 mice at 8 months

cellular
• scattered foci of hepatic necrosis in LPS-treated mice

mortality/aging
N
• mice do not become sick enough to require euthanasia unlike Zfp36tm1.2Xen homozygotes

immune system
• in some mice
• in LPS-treated mice
• modest at 3 to 4 months in female mice
• 110 fold in LPS-treated mice
• in some mice
• widespread inflammatory cell infiltrates in liver, kidney, and lung in LPS-treated mice
• LPS-treated mice exhibit dramatic signs of endotoxemia (lethargy, tachypnea, piloerection and decreased body temperature); elevated TNF serum levels; enlarged spleens and dilated small intestines, with widespread inflammatory cell infiltrates in liver, kidney, and lung; scattered foci of hepatic necrosis, glomerular hypercellularity, and pulmonary alveolitis; and 5-fold increase in serum alanine aminotransferase, a 2.2-fold increase in blood urea nitrogen, and a 3-fold increase in lactate dehydrogenase compared with control mice
• mild interphalangeal arthritis and inflammation in 1 of 4 mice
• in LPS-treated mice

homeostasis/metabolism
• 2.2-fold in LPS-treated mice
• 110 fold in LPS-treated mice
• dramatic in LPS-treated mice
• 3-fold in LPS-treated mice

behavior/neurological
• dramatic in LPS-treated mice
• dramatic in LPS-treated mice

respiratory system
• in LPS-treated mice
• dramatic in LPS-treated mice

cardiovascular system
• mild inflammation and fibrosis in 3 of 4 mice at 8 months

growth/size/body
• at 6.5 months in female mice
• at 9 months in male mice

digestive/alimentary system
• dilated in LPS-treated mice

liver/biliary system
• scattered foci of hepatic necrosis in LPS-treated mice

hematopoietic system
• in some mice
• in LPS-treated mice
• modest at 3 to 4 months in female mice

renal/urinary system
• glomerular hypercellularity in LPS-treated mice

skeleton
• mild interphalangeal arthritis and inflammation in 1 of 4 mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/19/2020
MGI 6.15
The Jackson Laboratory