Mouse Genome Informatics
tg1
    Tg(Vav1-JAK2*V617F)AZjz/0
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• 75% of mutants exhibit a strong elevation of platelets but with normal or slightly increased counts of white blood and red blood cells, resembling essential thrombocythemia
• 25% of mutants show abnormally high levels of red blood cells and white blood cells as well as platelets, resembling polycythemia vera
• bone marrow and spleen give rise to an increase in hematopoietic colonies, indicating the presence of a larger percentage of progenitor cells
• bone marrow cells produce an increased number of granulocyte-macrophage colony-forming cell colonies compared to controls in the absence of growth factors
• mutants exhibit autonomous formation of erythrocyte colony-forming unit colonies with cells from bone marrow
• erythroid hyperplasia in the spleen and bone marrow
• mutants exhibit many smaller red blood cells
• mutants exhibit increased number of platelets with the occasional presence of giant platelets
• mutants exhibit an increase in the number of megakaryocytic progenitor cells in the bone marrow
• megakaryocytic hyperplasia in the spleen and bone marrow
• spleens weigh 2-8 times more than those of controls
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen

homeostasis/metabolism
• plasma thyroid peroxidase levels are decreased

immune system
• spleens weigh 2-8 times more than those of controls
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen

skeleton
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen