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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fstl1tm1Nju
targeted mutation 1, Model Animal Research Center of Nanjing University
MGI:5440890
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fstl1tm1Nju/Fstl1tm1Nju
Tg(Scn10a-cre)1Rkun/0
involves: 129 * C57BL/6 * DBA MGI:5440896


Genotype
MGI:5440896
cn1
Allelic
Composition
Fstl1tm1Nju/Fstl1tm1Nju
Tg(Scn10a-cre)1Rkun/0
Genetic
Background
involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fstl1tm1Nju mutation (0 available); any Fstl1 mutation (29 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• small dorsal root ganglion neurons have a reduction in the number of FSTL1-immunoreactive vesicles
• firing rates are elevated in wide-dynamic range neurons and both innocuous (pressure) and noxious (pinch) stimuli induce a similar increase in firing rate
• the baseline of spontaneous excitatory postsynaptic current frequency in lamina II neurons is elevated
• the K+ induced frequency is increased

behavior/neurological
• reduced response threshold to von Frey mechanical stimuli applied to the hindpaw
• display exaggerated responses in both first and second phases of the nociceptive reaction after intradermal injection of 0.5% formalin
• reduced response latencies during radiant heat testing

integument
• reduced response threshold to von Frey mechanical stimuli applied to the hindpaw
• display exaggerated responses in both first and second phases of the nociceptive reaction after intradermal injection of 0.5% formalin
• reduced response latencies during radiant heat testing





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory