Mouse Genome Informatics
hm1
    Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
C57BL/6J-Psen1tm1.1Ruvi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
N
• male fertility is normal (J:187475)
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements (J:187475)

homeostasis/metabolism
• 20 times in female mice (J:187475)

endocrine/exocrine glands
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements (J:187475)


Mouse Genome Informatics
cx2
    Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Tg(APP)8.9Btla/0

involves: 129S2/SvPas * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• keratan sulfate-positive-activated microglia
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice
• in the cerebral cortex with amyloid deposition
• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles

immune system
• keratan sulfate-positive-activated microglia

hematopoietic system
• keratan sulfate-positive-activated microglia

homeostasis/metabolism
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice