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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1.1Ruvi
targeted mutation 1.1, Ruben Vidal
MGI:5439663
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1.1Ruvi/Psen1tm1.1Ruvi C57BL/6J-Psen1tm1.1Ruvi MGI:5439824
cx2
Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Tg(APP)8.9Btla/0
involves: 129S2/SvPas * C57BL/6J MGI:5439825


Genotype
MGI:5439824
hm1
Allelic
Composition
Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Genetic
Background
C57BL/6J-Psen1tm1.1Ruvi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male fertility is normal
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements

homeostasis/metabolism

endocrine/exocrine glands
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements




Genotype
MGI:5439825
cx2
Allelic
Composition
Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Tg(APP)8.9Btla/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation (0 available); any Psen1 mutation (28 available)
Tg(APP)8.9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• keratan sulfate-positive-activated microglia
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice
• in the cerebral cortex with amyloid deposition
• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles

immune system
• keratan sulfate-positive-activated microglia

hematopoietic system
• keratan sulfate-positive-activated microglia

homeostasis/metabolism
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory