About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rnf43tm1Cle
targeted mutation 1, Hans Clevers
MGI:5439364
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd MGI:5439368
cn2
Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Tg(Vil-cre/ERT2)23Syr/0
involves: C57BL/6 * DBA/2 MGI:5439367


Genotype
MGI:5439368
cn1
Allelic
Composition
Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (14 available)
Rnf43tm1Cle mutation (0 available); any Rnf43 mutation (17 available)
Znrf3tm1Cle mutation (0 available); any Znrf3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells

neoplasm
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells




Genotype
MGI:5439367
cn2
Allelic
Composition
Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Tg(Vil-cre/ERT2)23Syr/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf43tm1Cle mutation (0 available); any Rnf43 mutation (17 available)
Tg(Vil-cre/ERT2)23Syr mutation (0 available)
Znrf3tm1Cle mutation (0 available); any Znrf3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi
• increase in the number of Olfm4+ stem cells after tamoxifen treatment
• increased number after tamoxifen treatment
• form within 1 month of clonal deletion induced by low dose tamoxifen treatment
• contain Olfm4+ stem cells and Paneth cells

neoplasm
• contain Olfm4+ stem cells and Paneth cells
• form within 1 month of clonal deletion induced by low dose tamoxifen treatment

cellular
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen

endocrine/exocrine glands
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi
• increase in the number of Olfm4+ stem cells after tamoxifen treatment
• increased number after tamoxifen treatment





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory