Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation
(0 available);
any
Prox1 mutation
(43 available)
Tg(Camk2a-cre)20Kmik mutation
(1 available)
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nervous system
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• the dentate gyrus is small due to apoptosis from leaky cre expression
• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells
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• at P28, mossy cells are reduced in the hilus compared to in control mice
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• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation
(0 available);
any
Prox1 mutation
(43 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation
(1 available)
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nervous system
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• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice
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• at P28, mossy cells are reduced in the hilus compared to in control mice
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• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice
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Analysis Tools