Phenotypes associated with this allele

• Allele Symbol: Ank1^MRI23420
• Allele Name: MRI23420
• Allele ID: MGI:5438699
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ank1^MRI23420/Ank1^MRI23420	SJL/J-Ank1^MRI23420	MGI:5438702
ht2	Ank1^MRI23420/Ank1^+	SJL/J-Ank1^MRI23420	MGI:5438703

Genotype
MGI:5438702

hm1

• Allelic Composition: Ank1^MRI23420/Ank1^MRI23420
• Genetic Background: SJL/J-Ank1^MRI23420

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Microcytosis in Ank1^MRI23420/Ank1⁺ mice and spherocytosis and jaundice in Ank1^MRI23420/Ank1^MRI23420 mice

mortality/aging

neonatal lethality, incomplete penetrance ( J:187820 )

• fewer than expected mice are born indicating partial neonatal or prenatal lethality

• mice die between 12 and 48 hours after birth

postnatal lethality, complete penetrance ( J:187820 )

• mice die between 12 and 48 hours after birth

prenatal lethality, incomplete penetrance ( J:187820 )

• fewer than expected mice are born indicating partial neonatal or prenatal lethality

hematopoietic system

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

abnormal erythrocyte morphology ( J:187820 )

• severe fragmentation

poikilocytosis ( J:187820 )

• amorphous

spherocytosis ( J:187820 )

liver/biliary system

jaundice ( J:187820 )

immune system

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

growth/size/body

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malaria		DOID:12365		J:187820

Genotype
MGI:5438703

ht2

• Allelic Composition: Ank1^MRI23420/Ank1⁺
• Genetic Background: SJL/J-Ank1^MRI23420

Microcytosis in Ank1^MRI23420/Ank1⁺ mice and spherocytosis and jaundice in Ank1^MRI23420/Ank1^MRI23420 mice

growth/size/body

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:187820 )

• following malaria infection

hematopoietic system

anemia ( J:187820 )

abnormal erythrocyte morphology ( J:187820 )

• small with membrane bledding

increased erythrocyte cell number ( J:187820 )

polycythemia ( J:187820 )

• mild

decreased mean corpuscular hemoglobin ( J:187820 )

decreased mean corpuscular volume ( J:187820 )

hyperchromasia ( J:187820 )

microcytosis ( J:187820 )

thrombocytosis ( J:187820 )

abnormal spleen morphology ( J:187820 )

• reduced medulla and proliferation of the extramedullary compartment

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

increased erythrocyte osmotic fragility ( J:187820 )

• lyse at higher salt concentrations than wild-type cells

homeostasis/metabolism

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

immune system

abnormal spleen morphology ( J:187820 )

• reduced medulla and proliferation of the extramedullary compartment

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

decreased susceptibility to parasitic infection ( J:187820 )

• mice are resistant to malaria infection with reduced proportion of infected red blood cells, increased splenic clearance of red blood cells, increased intraerythrocytic parasite death and reduced mortality compared with wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:187820 )

• following malaria infection