About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ago4tm1.1Peco
targeted mutation 1.1, Paula E Cohen
MGI:5438526
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ago4tm1.1Peco/Ago4tm1.1Peco B6.129P2(FVB)-Ago4tm1.1Peco MGI:5438527


Genotype
MGI:5438527
hm1
Allelic
Composition		 Ago4tm1.1Peco/Ago4tm1.1Peco
Genetic
Background		 B6.129P2(FVB)-Ago4tm1.1Peco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago4tm1.1Peco mutation (1 available); any Ago4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:187588 )
N
• males and females are fertile although complete reproductive histories are not reported
abnormal male germ cell morphology ( J:187588 )
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
oligozoospermia ( J:187588 )
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
increased male germ cell apoptosis ( J:187588 )
• increased apoptosis within the prophase I layers of the seminiferous epithelium
decreased testis weight ( J:187588 )
• decreased by 13% compared to controls
abnormal male meiosis ( J:187588 )
• disruption of sex body formation and mislocalization of sex body components including the synaptonemal complex
• premature entry into meiosis
• fail to correctly silence X and Y chromosomes during meiosis
abnormal synaptonemal complex ( J:187588 )
• localization of SYCP1 indicates a defect in synaptonemal complex formation and or integrity within the sex body

cellular
abnormal male germ cell morphology ( J:187588 )
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
oligozoospermia ( J:187588 )
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
increased male germ cell apoptosis ( J:187588 )
• increased apoptosis within the prophase I layers of the seminiferous epithelium

endocrine/exocrine glands
decreased testis weight ( J:187588 )
• decreased by 13% compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory