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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ago4tm1.1Peco
targeted mutation 1.1, Paula E Cohen
MGI:5438526
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ago4tm1.1Peco/Ago4tm1.1Peco B6.129P2(FVB)-Ago4tm1.1Peco MGI:5438527


Genotype
MGI:5438527
hm1
Allelic
Composition
Ago4tm1.1Peco/Ago4tm1.1Peco
Genetic
Background
B6.129P2(FVB)-Ago4tm1.1Peco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago4tm1.1Peco mutation (1 available); any Ago4 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• males and females are fertile although complete reproductive histories are not reported
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
• increased apoptosis within the prophase I layers of the seminiferous epithelium
• decreased by 13% compared to controls
• disruption of sex body formation and mislocalization of sex body components including the synaptonemal complex
• premature entry into meiosis
• fail to correctly silence X and Y chromosomes during meiosis
• localization of SYCP1 indicates a defect in synaptonemal complex formation and or integrity within the sex body

cellular
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
• increased apoptosis within the prophase I layers of the seminiferous epithelium

endocrine/exocrine glands
• decreased by 13% compared to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory