Phenotypes associated with this allele

• Allele Symbol: Spib^tm1Ksho
• Allele Name: targeted mutation 1, Tsuneyasu Kaisho
• Allele ID: MGI:5438102
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spib^tm1Ksho/Spib^tm1Ksho	involves: C57BL/6J	MGI:5438103

Genotype
MGI:5438103

hm1

• Allelic Composition: Spib^tm1Ksho/Spib^tm1Ksho
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal Peyer's patch morphology ( J:187649 )

• Peyer's patch cells exhibit smaller bacterial load of Salmonella typhimurium and Yersinia enterocolitica compared with wild-type cells

increased susceptibility to bacterial infection ( J:187649 )

• in transfer experiments, intestinal microfold cells but not immune cells confer impaired immune response to Salmonella typhimurium compared with wild-type cells

• Peyer's patch cells exhibit smaller bacterial load of Yersinia enterocolitica compared with wild-type cells

digestive/alimentary system

digestive/alimentary phenotype ( J:187649 )

N • mice exhibit normal goblet, Paneth and enteroendocrine cell differentiation

abnormal intestine morphology ( J:187649 )

• intestinal microfold cells exhibit impaired RANKL-induced differentiation compared to in wild-type mice

• in transfer experiments, differentiation defect is cell intrinsic