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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pabpc1ltm1.1Esel
targeted mutation 1.1, Emre Seli
MGI:5437740
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pabpc1ltm1.1Esel/Pabpc1ltm1.1Esel involves: 129S1/SvImJ * C57BL/6J MGI:5437751


Genotype
MGI:5437751
hm1
Allelic
Composition		 Pabpc1ltm1.1Esel/Pabpc1ltm1.1Esel
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pabpc1ltm1.1Esel mutation (1 available); any Pabpc1l mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle morphology ( J:187525 )
• some follicles have 2 or 3 layers of granulosa cells indicating the beginnings of premature antrum formation
increased secondary ovarian follicle number ( J:187525 )
• 3-fold increase in number of secondary follicles
polyovular ovarian follicle ( J:187525 )
• some follicles house 2 oocytes
abnormal oogenesis ( J:187525 )
• increased oocyte retention
abnormal oocyte morphology ( J:187525 )
• longated shapes, pronounced cytoplasmic granularity and abnormal polar-body-like structure
decreased oocyte number ( J:187525 )
• fewer total oocytes and no mature MII oocytes are detected
abnormal female meiosis ( J:187525 )
• abnormal spindle formation and chromosome alignment at the metaphase plate
decreased ovulation rate ( J:187525 )
• impaired ovulation
female infertility ( J:187525 )
• despite normal estrous cycle and mating behavior
impaired fertilization ( J:187525 )
• after super-ovulation of female mice and breeding with wild-type males, no two-cell embryos are collected 42 h later

cellular
abnormal oocyte morphology ( J:187525 )
• longated shapes, pronounced cytoplasmic granularity and abnormal polar-body-like structure
decreased oocyte number ( J:187525 )
• fewer total oocytes and no mature MII oocytes are detected
abnormal cell physiology ( J:187525 )
• maternal genes fail to be polyadenylated

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:187525 )
• some follicles have 2 or 3 layers of granulosa cells indicating the beginnings of premature antrum formation
increased secondary ovarian follicle number ( J:187525 )
• 3-fold increase in number of secondary follicles
polyovular ovarian follicle ( J:187525 )
• some follicles house 2 oocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory