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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shank2tm1Mgle
targeted mutation 1, Min Goo Lee
MGI:5437479
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Shank2tm1Mgle/Shank2tm1Mgle B6.129S4-Shank2tm1Mgle MGI:5437480
ht2
Shank2tm1Mgle/Shank2+ B6.129S4-Shank2tm1Mgle MGI:5437481


Genotype
MGI:5437480
hm1
Allelic
Composition
Shank2tm1Mgle/Shank2tm1Mgle
Genetic
Background
B6.129S4-Shank2tm1Mgle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1Mgle mutation (0 available); any Shank2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in males and females in an elevated plus maze (J:186718)
• in males and females in an elevated plus maze (J:186718)
• in males in a novel object recognition arena (J:186718)
• in males in a novel object recognition arena (J:186718)
• impaired spatial memory in a Morris water maze (J:186718)
• impaired spatial memory in a Morris water maze (J:186718)
• impaired spatial learning in a Morris water maze (J:186718)
• impaired spatial learning in a Morris water maze (J:186718)
• when housed alone, males show enhanced jumping mostly mixed with upright scrabbling, normal grooming, and decreased digging behaviors (J:186718)
• females show similar repetitive jumping compared to male mice (J:186718)
• when housed alone, males show enhanced jumping mostly mixed with upright scrabbling, normal grooming, and decreased digging behaviors (J:186718)
• females show similar repetitive jumping compared to male mice (J:186718)
• in males and females in an open field test (J:186718)
• in males and females in an open field test (J:186718)
• females display less efficient pup retrieval (J:186718)
• females display less efficient pup retrieval (J:186718)
• males housed alone show impaired nesting behavior (J:186718)
• males housed alone show impaired nesting behavior (J:186718)
• reduced interaction with target wild-type mice in a home cage assay (J:186718)
• in a 3 chamber assay preference for a novel mouse over a novel object is not as strong as in wild-type mice (J:186718)
• however, preference for a novel mouse over a familiar mouse is similar to wild-type (J:186718)
• treatment with 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) substantially improves social interaction but not other behaviors (J:186718)
• reduced interaction with target wild-type mice in a home cage assay (J:186718)
• in a 3 chamber assay preference for a novel mouse over a novel object is not as strong as in wild-type mice (J:186718)
• however, preference for a novel mouse over a familiar mouse is similar to wild-type (J:186718)
• treatment with 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) substantially improves social interaction but not other behaviors (J:186718)
• males allowed to interact with a wild-type female vocalize less frequently and take longer to make the first call compared to wild-type males (J:186718)
• males allowed to interact with a wild-type female vocalize less frequently and take longer to make the first call compared to wild-type males (J:186718)

nervous system
N
• grossly normal brain structures (J:186718)
• excitatory and inhibitory synapses are similar to wild-type controls (J:186718)
• grossly normal brain structures (J:186718)
• excitatory and inhibitory synapses are similar to wild-type controls (J:186718)
• decrease in the NMDA/AMPA ratio (J:186718)
• decrease in the NMDA/AMPA ratio (J:186718)
• long term potentiation induced by high frequency stimulation or theta burst stimulation is severely impaired (J:186718)
• long term potentiation induced by high frequency stimulation or theta burst stimulation is severely impaired (J:186718)
• long term depression induced by low frequency stimulation is completely abolished (J:186718)
• long term depression induced by low frequency stimulation is completely abolished (J:186718)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, 17; AUTS17 613436 J:186718




Genotype
MGI:5437481
ht2
Allelic
Composition
Shank2tm1Mgle/Shank2+
Genetic
Background
B6.129S4-Shank2tm1Mgle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1Mgle mutation (0 available); any Shank2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no defects in social interaction, repetitive behaviors or anxiety-like behaviors unlike in homozygous mice (J:186718)
• no defects in social interaction, repetitive behaviors or anxiety-like behaviors unlike in homozygous mice (J:186718)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory