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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1.1Wrst
targeted mutation 1.1, Wolfgang Wurst
MGI:5436308
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1.1Wrst/Pink1tm1.1Wrst involves: 129S2/SvPas * BALB/cJ * C57BL/6J MGI:5436309
cn2
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:6113544
cx3
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:6113417
cx4
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Tg(Prnp-SNCA*A53T)AAub/?
involves: 129S2/SvPas * C57BL/6J * FVB/N MGI:6113412


Genotype
MGI:5436309
hm1
Allelic
Composition
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129S2/SvPas * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected
• no decrease in striatal dopamine content is detected at 6 months of age
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological
N
• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls
• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age
• maximum contact is increased in the hindpaws in males at 26 months of age
• marked change in interpaw coordination
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular
• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive early-onset Parkinson disease 6 DOID:0060369 OMIM:605909
J:183290




Genotype
MGI:6113544
cn2
Allelic
Composition
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7Gt(XE726)Byg mutation (1 available); any Park7 mutation (46 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (25 available)
Rrn3tm1.1Igt mutation (0 available); any Rrn3 mutation (35 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants
• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants




Genotype
MGI:6113417
cx3
Allelic
Composition
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7Gt(XE726)Byg mutation (1 available); any Park7 mutation (46 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• mice do not exhibit impaired nucleolar activity in dopaminergic neurons with unaltered rDNA transcription




Genotype
MGI:6113412
cx4
Allelic
Composition
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Tg(Prnp-SNCA*A53T)AAub/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (25 available)
Tg(Prnp-SNCA*A53T)AAub mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice show a reduced life span

nervous system
• nucleolar integrity is disrupted in dopaminergic neurons, with the percentage of TH+ dopaminergic neurons containing one nucleolus being lower in the substantia nigra and ventral tagmental area and an increase in the percentage of dopaminergic neurons showing no nucleolar staining
• number of dopaminergic neurons containing 2 or 3 nucleoli is higher

cellular
• nucleolar integrity is disrupted in dopaminergic neurons, with the percentage of TH+ dopaminergic neurons containing one nucleolus being lower in the substantia nigra and ventral tagmental area and an increase in the percentage of dopaminergic neurons showing no nucleolar staining
• number of dopaminergic neurons containing 2 or 3 nucleoli is higher
• nucleolar activity is altered with downregulation in a subset of dopaminergic neurons while upregulation of rRNA synthesis is seen in another group of dopaminergic neurons suggesting initial compensatory mechanisms





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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory