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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1.1Wrst
targeted mutation 1.1, Wolfgang Wurst
MGI:5436308
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1.1Wrst/Pink1tm1.1Wrst involves: 129S2/SvPas * BALB/cJ * C57BL/6J MGI:5436309


Genotype
MGI:5436309
hm1
Allelic
Composition
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129S2/SvPas * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no decrease in striatal dopamine content is detected at 6 months of age
• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological
N
• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls
• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age
• maximum contact is increased in the hindpaws in males at 26 months of age
• marked change in interpaw coordination
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular
• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 6, Autosomal Recessive Early-Onset; PARK6 605909 J:183290





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory