Mouse Genome Informatics
hm1
    Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129S2/SvPas * BALB/cJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected (J:183290)
• no decrease in striatal dopamine content is detected at 6 months of age (J:183290)
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological
N
• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls (J:183290)
• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age (J:183290)
• maximum contact is increased in the hindpaws in males at 26 months of age (J:183290)
• marked change in interpaw coordination (J:183290)
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular
• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity (J:183290)