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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fktntm1Kcam
targeted mutation 1, Kevin P Campbell
MGI:5435571
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fktntm1Kcam/Fktntm1Kcam involves: 129S/SvEv MGI:5435606
cn2
Fktntm1Kcam/Fktntm1Kcam
Myf5tm3(cre)Sor/Myf5+
involves: 129S/SvEv * 129S4/SvJaeSor MGI:5435676
cn3
Fktntm1Kcam/Fktntm1Kcam
Tg(CAG-cre/Esr1*)5Amc/?
involves: 129S/SvEv * C57BL/6 * CBA MGI:5435674
cn4
Fktntm1Kcam/Fktntm1Kcam
Tg(Ckmm-cre)5Khn/?
involves: 129S/SvEv * FVB MGI:5435675


Genotype
MGI:5435606
hm1
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5435676
cn2
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Myf5tm3(cre)Sor/Myf5+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (20 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 11% die before 20 weeks of age even with special feeding
• remainder are dead or euthanized by 35 weeks

growth/size/body
• significantly under weight
• combined gastrocnemius and soleus weight is low

muscle
• moderate to severe dystrophic features in the iliopsoas muscle at 20 weeks

homeostasis/metabolism
• elevated at 4 and 8 weeks

behavior/neurological
• forelimb grip strength is reduced

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fukuyama congenital muscular dystrophy DOID:0050559 OMIM:253800
J:187144




Genotype
MGI:5435674
cn3
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (20 available)
Tg(CAG-cre/Esr1*)5Amc mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• iliopsoas muscle from mice treated with tamoxifen show indications of dystrophic disease
• variations in fiber size
• necrosis
• increase in centrally nucleated fibers

homeostasis/metabolism
• levels begin to rise at 14 weeks of age and are significantly elevated at 16-20 weeks after tamoxifen treatment at 10 weeks of age

growth/size/body
N
• normal body weight at 4- 20 weeks of age after tamoxifen treatment

behavior/neurological
N
• normal forelimb grip strength at 4-20 weeks of age after tampxifen treatment
• normal open field activity at 4-20 weeks of age after tampxifen treatment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fukuyama congenital muscular dystrophy DOID:0050559 OMIM:253800
J:187144




Genotype
MGI:5435675
cn4
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Tg(Ckmm-cre)5Khn/?
Genetic
Background
involves: 129S/SvEv * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (20 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• signs of dystrophic disease at 12 weeks of age
• central nucleation in muscle fibers
• variable fiber size
• hypercontracted fibers

homeostasis/metabolism
• elevated serum creatine kinase at 12 weeks of age

behavior/neurological
• reduced running times on a treadmill

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fukuyama congenital muscular dystrophy DOID:0050559 OMIM:253800
J:187144





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory