Mouse Genome Informatics
hm1
    Galnt3tcal/Galnt3tcal
involves: C3H * C57BL/6J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Ectopic calcifications, testicular abnormalities, and increased apoptosis in Galnt3tcal/Galnt3tcal mice

reproductive system
• disorganized
• increased apoptosis in both the lumen and the periphery
• reduced in number

skeleton
• at 12 weeks of age
• significantly increased in the tibiae

renal/urinary system
• ectopic calcification in the kidney
• increased apoptosis of interstitial cells of the renal medulla

integument
• ectopic calcification in cutaneous striated muscle

cardiovascular system
• ectopic calcification of the testicular artery
• ectopic calcification in the aorta
• ectopic calcification in the heart

digestive/alimentary system
• ectopic calcification of the tongue

homeostasis/metabolism
• elevated plasma phosphate
• in the soft tissue of the knee, elbow, and shoulder
• elevated plasma levels of 1,25-dihydroxy vitamin D

craniofacial
• ectopic calcification of the tongue

endocrine/exocrine glands
• disorganized
• increased apoptosis in both the lumen and the periphery
• reduced in number

growth/size/body
• ectopic calcification of the tongue

Mouse Models of Human Disease
OMIM IDRef(s)
Tumoral Calcinosis, Hyperphosphatemic, Familial; HFTC 211900 J:187064