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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Galnt3tcal
Familial Tumoural Calcinosis
MGI:5435287
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Galnt3tcal/Galnt3tcal involves: C3H * C57BL/6J MGI:5435288


Genotype
MGI:5435288
hm1
Allelic
Composition
Galnt3tcal/Galnt3tcal
Genetic
Background
involves: C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galnt3tcal mutation (1 available); any Galnt3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ectopic calcifications, testicular abnormalities, and increased apoptosis in Galnt3tcal/Galnt3tcal mice

cellular

reproductive system
• disorganized
• increased apoptosis in both the lumen and the periphery
• reduced in number

skeleton
• at 12 weeks of age
• significantly increased in the tibiae

renal/urinary system
• ectopic calcification in the kidney
• increased apoptosis of interstitial cells of the renal medulla

integument
• ectopic calcification in cutaneous striated muscle

cardiovascular system
• ectopic calcification of the testicular artery
• ectopic calcification in the aorta
• ectopic calcification in the heart

digestive/alimentary system
• ectopic calcification of the tongue

homeostasis/metabolism
• elevated plasma phosphate
• in the soft tissue of the knee, elbow, and shoulder
• elevated plasma levels of 1,25-dihydroxy vitamin D

craniofacial
• ectopic calcification of the tongue

endocrine/exocrine glands
• disorganized
• increased apoptosis in both the lumen and the periphery
• reduced in number

growth/size/body
• ectopic calcification of the tongue

Mouse Models of Human Disease
OMIM ID Ref(s)
Tumoral Calcinosis, Hyperphosphatemic, Familial; HFTC 211900 J:187064





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory