Phenotypes associated with this allele

• Allele Symbol: Fblim1^tm1.1Chen
• Allele Name: targeted mutation 1.1, Ju Chen
• Allele ID: MGI:5432800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fblim1^tm1.1Chen/Fblim1^tm1.1Chen	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5432803

Genotype
MGI:5432803

hm1

• Allelic Composition: Fblim1^tm1.1Chen/Fblim1^tm1.1Chen
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast differentiation ( J:186501 )

• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice

abnormal osteoclast differentiation ( J:186501 )

• mice exhibit increased osteoclast differentiation compared with wild-type mice

increased osteoclast cell number ( J:186501 )

• with increased primary and secondary spongiosa

abnormal osteoclast physiology ( J:186501 )

• mice exhibit increased osteoclast activity compared with wild-type mice

decreased bone mineral density ( J:186501 )

• severe

decreased bone volume ( J:186501 )

decreased osteoblast cell number ( J:186501 )

abnormal trabecular bone morphology ( J:186501 )

• increased trabecular space

decreased bone trabecula number ( J:186501 )

cellular

increased apoptosis ( J:186501 )

• of bone marrow derived stromal cells

abnormal osteoblast differentiation ( J:186501 )

• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice

abnormal osteoclast differentiation ( J:186501 )

• mice exhibit increased osteoclast differentiation compared with wild-type mice

decreased cell proliferation ( J:186501 )

• of bone marrow derived stromal cells

immune system

abnormal osteoclast differentiation ( J:186501 )

• mice exhibit increased osteoclast differentiation compared with wild-type mice

increased osteoclast cell number ( J:186501 )

• with increased primary and secondary spongiosa

abnormal osteoclast physiology ( J:186501 )

• mice exhibit increased osteoclast activity compared with wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:186501 )

• mice exhibit increased osteoclast differentiation compared with wild-type mice

increased osteoclast cell number ( J:186501 )

• with increased primary and secondary spongiosa

abnormal osteoclast physiology ( J:186501 )

• mice exhibit increased osteoclast activity compared with wild-type mice