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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fblim1tm1.1Chen
targeted mutation 1.1, Ju Chen
MGI:5432800
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fblim1tm1.1Chen/Fblim1tm1.1Chen involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5432803


Genotype
MGI:5432803
hm1
Allelic
Composition
Fblim1tm1.1Chen/Fblim1tm1.1Chen
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fblim1tm1.1Chen mutation (0 available); any Fblim1 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice
• mice exhibit increased osteoclast differentiation compared with wild-type mice
• with increased primary and secondary spongiosa
• mice exhibit increased osteoclast activity compared with wild-type mice
• increased trabecular space

cellular
• of bone marrow derived stromal cells
• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice
• mice exhibit increased osteoclast differentiation compared with wild-type mice
• of bone marrow derived stromal cells

immune system
• mice exhibit increased osteoclast differentiation compared with wild-type mice
• with increased primary and secondary spongiosa
• mice exhibit increased osteoclast activity compared with wild-type mice

hematopoietic system
• mice exhibit increased osteoclast differentiation compared with wild-type mice
• with increased primary and secondary spongiosa
• mice exhibit increased osteoclast activity compared with wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory