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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fam20ctm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5432377
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fam20ctm1Lex/Fam20ctm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5432491


Genotype
MGI:5432491
hm1
Allelic
Composition
Fam20ctm1Lex/Fam20ctm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam20ctm1Lex mutation (1 available); any Fam20c mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 20% mortality of homozygotes at 2 weeks of age

growth/size/body
• enlarged pulp chambers
• pulp necrosis in molars and apical abscesses
• pulp necrosis in molars
• peg-like with defective enamel
• initially scattered basophilic vacuoles in a dentin matrix
• later loss of dentin tubules and irregular distribution
• thinning of dentin layer
• defects in primary and secondary dentin
• near total lack of enamel on teeth
• narrow irregular roots
• decreased body mass measurements
• stunted growth
• bloated abdomen

behavior/neurological
• increased pre-shock, trace, and post-shock freezing during training in context-trace conditioning
• reduced mean ambulatory counts in both light and dark phase
• decreased median sum total distance travelled in open field tests

skeleton
• enlarged pulp chambers
• pulp necrosis in molars and apical abscesses
• pulp necrosis in molars
• peg-like with defective enamel
• initially scattered basophilic vacuoles in a dentin matrix
• later loss of dentin tubules and irregular distribution
• thinning of dentin layer
• defects in primary and secondary dentin
• near total lack of enamel on teeth
• narrow irregular roots
• thickened mandible
• decreased mean femoral mid shaft cortical thickness
• decreased vertebral trabecular bone volume
• decreased mean femoral mid shaft cortical thickness
• marked reduction of cartilage in newly formed trabeculae
• trabeculae nearly absent in long bones of young mice but increased in older mice
• narrow spongiosa with thick irregular osteoid bands
• metaphyseal osteosclerosis
• thickened and disorganized growth plate cartilage
• fragile bones

craniofacial
• enlarged pulp chambers
• pulp necrosis in molars and apical abscesses
• pulp necrosis in molars
• peg-like with defective enamel
• initially scattered basophilic vacuoles in a dentin matrix
• later loss of dentin tubules and irregular distribution
• thinning of dentin layer
• defects in primary and secondary dentin
• near total lack of enamel on teeth
• narrow irregular roots
• thickened mandible

hearing/vestibular/ear
• lack of startle response in prepulse inhibition test

nervous system
• lack of startle response in prepulse inhibition test

vision/eye
• increased lacrimal discharge and crusting around the eyes

homeostasis/metabolism

hematopoietic system
• in spleen and liver

renal/urinary system
• lack of secondary hormone dependent differentiation of parietal epithelium cells in Bowman's capsule in males

reproductive system

digestive/alimentary system
• lack of secondary hormone dependent differentiation of tubular epithelium in salivary glands of mature males

endocrine/exocrine glands
• lack of secondary hormone dependent differentiation of tubular epithelium in salivary glands of mature males
• increased lacrimal discharge and crusting around the eyes

limbs/digits/tail
• decreased mean femoral mid shaft cortical thickness

cellular
• pulp necrosis in molars





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory