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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(YAC128)55Hay
transgene insertion 55, Michael Hayden
MGI:5432147
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(YAC128)55Hay/Tg(YAC128)55Hay FVB/N-Tg(YAC128)55Hay MGI:5432190
tg2
Tg(YAC128)55Hay/0 FVB/N-Tg(YAC128)55Hay MGI:5432192


Genotype
MGI:5432190
tg1
Allelic
Composition
Tg(YAC128)55Hay/Tg(YAC128)55Hay
Genetic
Background
FVB/N-Tg(YAC128)55Hay
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• general increase in stress-induced apoptosis in primary cultures of striatal neurons
• in cultured striatal medium spiny neurons in response to mitochondria stress
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)
• decrease in striatal volume at 12 months of age
• at 18 months of age in the striatum and cortex

behavior/neurological
• beginning at 4 months of age and becoming worse with age
• disease progression is slower than in mice hemizygous forTg(YAC128)53Hay but faster than in hemizygous mice
• approaches statistical significance at 12 months of age

cellular
• general increase in stress-induced apoptosis in primary cultures of striatal neurons
• in cultured striatal medium spiny neurons in response to mitochondria stress
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)

homeostasis/metabolism
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:105723 , J:105728




Genotype
MGI:5432192
tg2
Allelic
Composition
Tg(YAC128)55Hay/0
Genetic
Background
FVB/N-Tg(YAC128)55Hay
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no neuronal inclusions are detected at 18 months of age in the cortex or striatum
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type
• decrease in striatal volume at 12 months of age
• volume is increased compared to mice hemizygous for Tg(YAC128)53Hay

behavior/neurological
• late onset, beginning at 9 months of age
• disease progression is slower than in mice hemizygous for Tg(YAC128)53Hay or homozygous mice

cellular
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

homeostasis/metabolism
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:105723





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory