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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fig4tm1.1Mm
targeted mutation 1.1. Miriam H Meisler
MGI:5431009
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fig4tm1.1Mm/Fig4tm1.1Mm
Tg(Syn1-cre)671Jxm/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5431086


Genotype
MGI:5431086
cn1
Allelic
Composition
Fig4tm1.1Mm/Fig4tm1.1Mm
Tg(Syn1-cre)671Jxm/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fig4tm1.1Mm mutation (0 available); any Fig4 mutation (51 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival to 5 months of age but severely weakened

behavior/neurological
• severe movement disorder by 30 days of age
• both forelimb and hind limb clasping in tail suspension tests at 3 months of age

nervous system
• low level of astrocyte dysfunction
• in deep layers of cortex, cerebellar nuclei, hippocampus, brainstem, and dorsal root ganglia

growth/size/body
• body weight reductions are modest, weights of about 17g

integument
N
• normal coat color (not diluted)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory