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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aim2tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5428935
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Aim2tm1.1Vmd/Aim2tm1.1Vmd C57BL/6-Aim2tm1.1Vmd MGI:5428936


Genotype
MGI:5428936
hm1
Allelic
Composition
Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic
Background
C57BL/6-Aim2tm1.1Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aim2tm1.1Vmd mutation (0 available); any Aim2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• improved cell viability following transfection with poly(dA:dT) or pcDNA3
• improved bone marrow derived macrophage viability following infection with F. tularensis
• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3
• in LPS-primed bone marrow derived macrophages or peritoneal macrophages stimulated by dsDNA
• bone marrow derived macrophages do not secrete IL1B in response to F. tularensis
• in LPS-primed bone marrow derived macrophages stimulated by dsDNA
• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3
• fail to control F. tularensis infection

hematopoietic system
• improved cell viability following transfection with poly(dA:dT) or pcDNA3
• improved bone marrow derived macrophage viability following infection with F. tularensis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory