Mouse Genome Informatics
cx1
    Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0

B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:184496


Mouse Genome Informatics
cx2
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0

B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• 40% of double mutants exhibit lung metastasis which is not seen in single Tg(Pklr-Myc)73Ak mice
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:184496


Mouse Genome Informatics
tg3
    Tg(Pklr-Myc)73Ak/0
B6.Cg-Tg(Pklr-Myc)73Ak
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis

immune system
• the proportion of invariant NKT cells in the liver is lower than in controls

hematopoietic system
• the proportion of invariant NKT cells in the liver is lower than in controls

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:184496


Mouse Genome Informatics
tg4
    Tg(Pklr-Myc)73Ak/0
involves: C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mutants fed a carbohydrate-rich diet develop hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
• mutants fed a carbohydrate-rich diet frequently develop hepatomas

endocrine/exocrine glands
• mutants fed a carbohydrate-rich diet exhibit pancreatic islet hyperplasia, however they do not develop pancreatic tumors

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:185488