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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pklr-Myc)73Ak
transgene insertion 73, Axel Kahn
MGI:5428913
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0
B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak MGI:5430590
cx2
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0
B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak MGI:5430591
tg3
Tg(Pklr-Myc)73Ak/0 B6.Cg-Tg(Pklr-Myc)73Ak MGI:5430592
tg4
Tg(Pklr-Myc)73Ak/0 involves: C57BL/6 * DBA MGI:5428914


Genotype
MGI:5430590
cx1
Allelic
Composition
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0
Genetic
Background
B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lect2tm1Ymg mutation (0 available); any Lect2 mutation (4 available)
Tg(Pklr-Myc)73Ak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

neoplasm
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:184496




Genotype
MGI:5430591
cx2
Allelic
Composition
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0
Genetic
Background
B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

neoplasm
• 40% of double mutants exhibit lung metastasis which is not seen in single Tg(Pklr-Myc)73Ak mice
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:184496




Genotype
MGI:5430592
tg3
Allelic
Composition
Tg(Pklr-Myc)73Ak/0
Genetic
Background
B6.Cg-Tg(Pklr-Myc)73Ak
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

neoplasm

immune system
• the proportion of invariant NKT cells in the liver is lower than in controls

hematopoietic system
• the proportion of invariant NKT cells in the liver is lower than in controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:184496




Genotype
MGI:5428914
tg4
Allelic
Composition
Tg(Pklr-Myc)73Ak/0
Genetic
Background
involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants fed a carbohydrate-rich diet develop hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
• mutants fed a carbohydrate-rich diet frequently develop hepatomas

neoplasm
• mutants fed a carbohydrate-rich diet develop hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
• mutants fed a carbohydrate-rich diet frequently develop hepatomas

endocrine/exocrine glands
• mutants fed a carbohydrate-rich diet exhibit pancreatic islet hyperplasia, however they do not develop pancreatic tumors

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:185488





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory