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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Disc1/EGFP)M19Sshe
transgene insertion M19, Sanbing Shen
MGI:5428215
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Disc1/EGFP)M19Sshe/0 involves: C57BL/6JCrl * CBA/CaCrl MGI:5428306


Genotype
MGI:5428306
tg1
Allelic
Composition
Tg(Disc1/EGFP)M19Sshe/0
Genetic
Background
involves: C57BL/6JCrl * CBA/CaCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus
• reduced brain volume and total surface
• 2.3- to 3.0-fold
• 2.26 times and 2.98 times
• partial agenesis
• thin and fails to cross the midline above the subcommissural organ
• shorter and fewer neurites than on wild-type neurons
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus

behavior/neurological
• mice exhibit increased immobility in depression tests compared with wild-type mice
• mice exhibit reduced stress calls during depression tests compared with wild-type mice

cellular
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:143557





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory