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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fcgr2btm1.2Jsv
targeted mutation 1.2, J Sjef Verbeek
MGI:5427927
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N MGI:5427953
cx2
Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6
involves: C57BL/6 * FVB/N MGI:5427949
cx3
Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
involves: C57BL/6 * FVB/N * SB/Le MGI:5427950


Genotype
MGI:5427953
cx1
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
Genetic
Background
involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21C57BL/6 mutation (0 available); any Sle21 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system
• not as severe as in Fcgr2btm1Ttk homozygotes
• not as severe as in Fcgr2btm1Ttk homozygotes
• not as severe as in Fcgr2btm1Ttk homozygotes
• not as severe as in Fcgr2btm1Ttk homozygotes

renal/urinary system
• not as severe as in Fcgr2btm1Ttk homozygotes
• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism
• not as severe as in Fcgr2btm1Ttk homozygotes

hematopoietic system
• not as severe as in Fcgr2btm1Ttk homozygotes
• not as severe as in Fcgr2btm1Ttk homozygotes

growth/size/body
• not as severe as in Fcgr2btm1Ttk homozygotes
• not as severe as in Fcgr2btm1Ttk homozygotes




Genotype
MGI:5427949
cx2
Allelic
Composition
Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Sle16C57BL/6 mutation (0 available); any Sle16 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mild
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
• at 8 months, mice develop mild nonlethal glomerular damage compared with wild-type mice

immune system
N
• unlike Fcgr2btm1Ttk homozygotes, mice do not develop high anti-nuclear antibodies titers spontaneously or increased spleen weight
• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

skeleton
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

homeostasis/metabolism
• in a nephrotoxic nephritis model
• mild

hematopoietic system
• kidney IgG and C3 depositions in a nephrotoxic nephritis model




Genotype
MGI:5427950
cx3
Allelic
Composition
Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
Genetic
Background
involves: C57BL/6 * FVB/N * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Yaa mutation (18 available); any Yaa mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit greater cumulative death compared with Fcgr2btm1.2Sjv homozygotes

immune system
• compared with Fcgr2btm1.2Sjv homozygotes
• compared with single homozygotes
• mice develop moderate lupus unlike Fcgr2btm1.2Sjv homozygotes
• however, mice do not develop fatal lupus
• compared with single homozygotes
• compared with single homozygotes

renal/urinary system
• kidney pathology is increased compared to in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
• compared with Fcgr2btm1.2Sjv homozygotes
• compared with single homozygotes

growth/size/body
• compared with Fcgr2btm1.2Sjv homozygotes





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory