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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr3tm2Llm
targeted mutation 2, Laurence Legeai-Mallet
MGI:5426422
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0
involves: 129S2/SvPas * C57BL/6 * FVB MGI:5426514
cn2
Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5426512
cn3
Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5426513


Genotype
MGI:5426514
cn1
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (18 available)
Tg(Col1a1-cre)1Kry mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• no obvious skeletal phenotype
• normal growth plates
• primary spongiosa is normal
• normal trabecular bone




Genotype
MGI:5426512
cn2
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (18 available)
Tg(CMV-cre)1Ipc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• severe dwarfism

skeleton
• reduced width of skull
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
• smaller hypertrophic mineralization zone
• reduced size of epiphysis
• defect in mineralization of calcified cartilage and primary spongiosa

craniofacial
• reduced width of skull

hematopoietic system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased

immune system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased




Genotype
MGI:5426513
cn3
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (18 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• dwarfism

skeleton
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
• smaller hypertrophic mineralization zone
• lack proliferative column organization
• proliferative zone reduced
• reduced hypertrophic zone
• small hypertrophic cells
• reduced size of epiphysis
• defect in mineralization of calcified cartilage and primary spongiosa
• delayed formation of secondary ossification centers

craniofacial

hematopoietic system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased

immune system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory