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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr3tm2Llm
targeted mutation 2, Laurence Legeai-Mallet
MGI:5426422
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0
involves: 129S2/SvPas * C57BL/6 * FVB MGI:5426514
cn2
Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5426512
cn3
Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5426513


Genotype
MGI:5426514
cn1
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (10 available)
Tg(Col1a1-cre)1Kry mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• no obvious skeletal phenotype (J:183772)
• normal growth plates (J:183772)
• primary spongiosa is normal (J:183772)
• normal trabecular bone (J:183772)
• no obvious skeletal phenotype (J:183772)
• normal growth plates (J:183772)
• primary spongiosa is normal (J:183772)
• normal trabecular bone (J:183772)




Genotype
MGI:5426512
cn2
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (10 available)
Tg(CMV-cre)1Ipc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• severe dwarfism (J:183772)
• severe dwarfism (J:183772)

skeleton
• reduced width of skull (J:183772)
• reduced width of skull (J:183772)
• narrow trunk (J:183772)
• narrow trunk (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• fewer subchondral trabeculae (J:183772)
• trabeculae only partially mineralized (J:183772)
• more abundant collagen deposition (J:183772)
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur (J:183772)
• fewer subchondral trabeculae (J:183772)
• trabeculae only partially mineralized (J:183772)
• more abundant collagen deposition (J:183772)
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur (J:183772)
• smaller hypertrophic mineralization zone (J:183772)
• smaller hypertrophic mineralization zone (J:183772)
• reduced size of epiphysis (J:183772)
• reduced size of epiphysis (J:183772)
• defect in mineralization of calcified cartilage and primary spongiosa (J:183772)
• defect in mineralization of calcified cartilage and primary spongiosa (J:183772)

craniofacial
• reduced width of skull (J:183772)
• reduced width of skull (J:183772)

hematopoietic system
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)

immune system
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)




Genotype
MGI:5426513
cn3
Allelic
Composition
Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation (0 available); any Fgfr3 mutation (10 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• dwarfism (J:183772)
• dwarfism (J:183772)

skeleton
• narrow trunk (J:183772)
• narrow trunk (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• fewer subchondral trabeculae (J:183772)
• trabeculae only partially mineralized (J:183772)
• more abundant collagen deposition (J:183772)
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur (J:183772)
• fewer subchondral trabeculae (J:183772)
• trabeculae only partially mineralized (J:183772)
• more abundant collagen deposition (J:183772)
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur (J:183772)
• smaller hypertrophic mineralization zone (J:183772)
• smaller hypertrophic mineralization zone (J:183772)
• lack proliferative column organization (J:183772)
• proliferative zone reduced (J:183772)
• proliferative zone reduced (J:183772)
• lack proliferative column organization (J:183772)
• reduced hypertrophic zone (J:183772)
• small hypertrophic cells (J:183772)
• reduced hypertrophic zone (J:183772)
• small hypertrophic cells (J:183772)
• reduced size of epiphysis (J:183772)
• reduced size of epiphysis (J:183772)
• defect in mineralization of calcified cartilage and primary spongiosa (J:183772)
• defect in mineralization of calcified cartilage and primary spongiosa (J:183772)
• delayed formation of secondary ossification centers (J:183772)
• delayed formation of secondary ossification centers (J:183772)

craniofacial

hematopoietic system
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)

immune system
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)
• osteoclasts per bone area are increased (J:183772)
• osteoclast surface area/bone surface area is increased (J:183772)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory