Mouse Genome Informatics
cn1
    Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0

involves: 129S2/SvPas * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
skeleton
N
• no obvious skeletal phenotype (J:183772)
• normal growth plates (J:183772)
• primary spongiosa is normal (J:183772)
• normal trabecular bone (J:183772)


Mouse Genome Informatics
cn2
    Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?

involves: 129S2/SvPas * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• severe dwarfism

skeleton
• reduced width of skull
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
• smaller hypertrophic mineralization zone
• reduced size of epiphysis
• defect in mineralization of calcified cartilage and primary spongiosa

craniofacial
• reduced width of skull

hematopoietic system
• osteoclast surface area/bone surface area is increased
• osteoclasts per bone area are increased

immune system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased


Mouse Genome Informatics
cn3
    Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?

involves: 129S2/SvPas * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• dwarfism

skeleton
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
• smaller hypertrophic mineralization zone
• lack proliferative column organization
• proliferative zone reduced
• reduced hypertrophic zone
• small hypertrophic cells
• reduced size of epiphysis
• defect in mineralization of calcified cartilage and primary spongiosa
• delayed formation of secondary ossification centers

craniofacial

hematopoietic system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased

immune system
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased