Mouse Genome Informatics
cn1
     Fgfr3tm2Llm/Fgfr3+
Tg(Col1a1-cre)1Kry/0
involves: 129S2/SvPas * C57BL/6 * FVB
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
skeleton
skeleton phenotype ( J:183772 )
N
• no obvious skeletal phenotype (J:183772)
• normal growth plates (J:183772)
• primary spongiosa is normal (J:183772)
• normal trabecular bone (J:183772)


Mouse Genome Informatics
cn2
     Fgfr3tm2Llm/Fgfr3+
Tg(CMV-cre)1Ipc/?
involves: 129S2/SvPas * C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
growth/size
decreased body size ( J:183772 )
• severe dwarfism

skeleton
abnormal long bone epiphyseal ossification zone morphology ( J:183772 )
• smaller hypertrophic mineralization zone
abnormal long bone epiphysis morphology ( J:183772 )
• reduced size of epiphysis
abnormal craniofacial bone morphology ( J:183772 )
• reduced width of skull
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
abnormal trabecular bone morphology ( J:183772 )
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
abnormal bone mineralization ( J:183772 )
• defect in mineralization of calcified cartilage and primary spongiosa

craniofacial
abnormal craniofacial bone morphology ( J:183772 )
• reduced width of skull

hematopoietic system
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased

immune system
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased


Mouse Genome Informatics
cn3
     Fgfr3tm2Llm/Fgfr3+
Tg(Col2a1-cre)1Bhr/?
involves: 129S2/SvPas * C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
growth/size
decreased body size ( J:183772 )
• dwarfism

skeleton
abnormal long bone epiphyseal ossification zone morphology ( J:183772 )
• smaller hypertrophic mineralization zone
abnormal long bone epiphyseal plate proliferative zone ( J:183772 )
• lack proliferative column organization
• proliferative zone reduced
decreased width of hypertrophic chondrocyte zone ( J:183772 )
• reduced hypertrophic zone
• small hypertrophic cells
abnormal long bone epiphysis morphology ( J:183772 )
• reduced size of epiphysis
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
abnormal trabecular bone morphology ( J:183772 )
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
abnormal bone mineralization ( J:183772 )
• defect in mineralization of calcified cartilage and primary spongiosa
delayed bone ossification ( J:183772 )
• delayed formation of secondary ossification centers

craniofacial

hematopoietic system
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased

immune system
increased osteoclast cell number ( J:183772 )
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased