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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mns1tm1Jw
targeted mutation 1, Jeremy Wang
MGI:5425368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mns1tm1Jw/Mns1tm1Jw involves: 129S4/SvJae * C57BL/6 MGI:5425369


Genotype
MGI:5425369
hm1
Allelic
Composition
Mns1tm1Jw/Mns1tm1Jw
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mns1tm1Jw mutation (1 available); any Mns1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected homozygotes are found, lethality occurs sometime before weaning

reproductive system
• axonemal microtubules and outer dense fibers are completely disorganized
• the sperm principal piece appears to be missing the fibrous sheath
• most (98%) sperm have a very short crooked tail
• most (98%) sperm have a very short crooked tail
• sperm count in the epididymides is reduced to 8% that of wild-type controls
• elongated spermatids appear to lack flagella
• at 8 weeks of age
• mostly filled with cell debris and contain few sperm

respiratory system
• tracheal motile cilia lack some outer dynein arms and contain only about 4 of them per cross section compared to 9 per cross section in wild-type controls
• randomized left-right patterning with 6 of 22 mice showing left-sided isomerism
• randomized left-right patterning with 8 of 22 mice showing situs inversus

nervous system
• starting at P4

growth/size/body
• randomized left-right patterning with 6 of 22 mice showing left-sided isomerism
• randomized left-right patterning with 8 of 22 mice showing situs inversus

endocrine/exocrine glands
• at 8 weeks of age

cellular
• tracheal motile cilia lack some outer dynein arms and contain only about 4 of them per cross section compared to 9 per cross section in wild-type controls
• axonemal microtubules and outer dense fibers are completely disorganized
• the sperm principal piece appears to be missing the fibrous sheath
• most (98%) sperm have a very short crooked tail
• most (98%) sperm have a very short crooked tail
• sperm count in the epididymides is reduced to 8% that of wild-type controls
• elongated spermatids appear to lack flagella





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory