Phenotypes associated with this allele

• Allele Symbol: Ddah1^tm1.1Yjch
• Allele Name: targeted mutation 1.1, Yingjie Chen
• Allele ID: MGI:5424370
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddah1^tm1.1Yjch/Ddah1^tm1.1Yjch	involves: 129S1/Sv * 129S4/SvJae	MGI:5424473

Genotype
MGI:5424473

hm1

• Allelic Composition: Ddah1^tm1.1Yjch/Ddah1^tm1.1Yjch
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:182373 )

N • heart weight, heart left ventricular dimensions and function are unchanged in homozygotes

increased systemic arterial blood pressure ( J:182373 )

• slightly elevated blood pressure

homeostasis/metabolism

abnormal amino acid level ( J:182373 )

• tissue levels of ADMA and L-NMMA are significantly increased in homozygous mice

abnormal circulating amino acid level ( J:182373 )

• plasma ADMA and L-NMMA levels are significantly increased in homozygous mice

abnormal nitric oxide homeostasis ( J:182373 )

• both urinary and plasma NOx content are significantly decreased in homozygotes

abnormal enzyme/coenzyme activity ( J:182373 )

• enzyme activity for degrading ADMA (asymmetrical dimethylarginine) and L-NMMA (N^g-mono-methyl-L-arginine) is undetectable in homozygous mice