Phenotypes associated with this allele

• Allele Symbol: tmm
• Allele Name: telencephalic midline malformation
• Allele ID: MGI:5320501
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	tmm/tmm	BXD29-Tlr4^lps-2J/J	MGI:5320587

Genotype
MGI:5320587

hm1

• Allelic Composition: tmm/tmm
• Genetic Background: BXD29-Tlr4^lps-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal hearing physiology ( J:184128 )

• mice exhibit a defect in rapid auditory processing as determined by silent gap test

nervous system

increased brain size ( J:184128 )

• total brain volume is increased by 10% as compared to controls

• volumes of individual regions (cerebellum, hippocampus, striatum, neocortex) are slightly but nonsignifcantly larger than controls

decreased corpus callosum size ( J:184128 )

• partial callosal agenesis

• midsagittal area of the corpus callosum is decreased by 50%

• decrease in callosal and cingulum fibers

abnormal cingulum morphology ( J:184128 )

• decrease in cingulum fibers

ectopic neuron ( J:184128 )

• bilateral nodular subcortical heterotopia comprised of neurons (CUX1+) destined for layers 2-4 of the neocortex

• heterotopia is located at the border between the retrosplenial cortex and somatosensory cortical regions

• heterotopia comprises 1.5 to 3% of neocortical volume

• neurons appear in heterotopia during mid to late gestation

behavior/neurological

behavior/neurological phenotype ( J:184128 )

N • mice perform similar to wild-type in tests for coordination (rotarod) and learning/memory (water maze)