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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhdtm1Goo
targeted mutation 1, Dominique Goossens
MGI:5318588
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhdtm1Goo/Rhdtm1Goo involves: 129P2/OlaHsd * C57BL/6 MGI:5318590
cx2
 		Rhagtm1Goo/Rhagtm1Goo
Rhdtm1Goo/Rhdtm1Goo 		involves: 129P2/OlaHsd * C57BL/6 MGI:5318591


Genotype
MGI:5318590
hm1
Allelic
Composition		 Rhdtm1Goo/Rhdtm1Goo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhdtm1Goo mutation (2 available); any Rhd mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte physiology ( J:182122 )
• the alkalinisation rate constant values for ghosts are reduced by 30-40% compared to wild-type red blood cells
• basal adhesion to bEnd.3 endothelial cells is reduced

homeostasis/metabolism
increased circulating iron level ( J:182122 )
• slightly increased at 17 weeks of age




Genotype
MGI:5318591
cx2
Allelic
Composition		 Rhagtm1Goo/Rhagtm1Goo
Rhdtm1Goo/Rhdtm1Goo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhagtm1Goo mutation (2 available); any Rhag mutation (25 available)
Rhdtm1Goo mutation (2 available); any Rhd mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:182122 )
N
• not anaemic and show no obvious anomalies in standard haematological parameters or in erythrocyte morphology or fragility

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182122 )
N
• no significant changes in iron, transferrin, or ferritin levels

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT Rh deficiency syndrome DOID:0050641 OMIM:268150
 J:182122




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory