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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc12a6tm1.1Garo
targeted mutation 1.1, Guy A Rouleau
MGI:5318539
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc12a6tm1.1Garo/Slc12a6tm1.1Garo involves: 129 * C57BL/6 MGI:5318541


Genotype
MGI:5318541
hm1
Allelic
Composition
Slc12a6tm1.1Garo/Slc12a6tm1.1Garo
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a6tm1.1Garo mutation (0 available); any Slc12a6 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• unable to successfully breed

nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age
• at 2 months of age
• the position in relation to the anterior commissure appears to be shifted
• significant decrease in the number of streamlines from the splenium passing through the external capsule adjacent to the somatosensory cortices
• hypoplastic with reduced length and surface area
• axon swelling in sciatic nerves
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
• in sciatic nerves
• hypomyelination in sciatic nerves

behavior/neurological
• baseline startle response is increased but mice fail increase startle amplitude with increasing intensities
• by 3-4 weeks of age
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size/body
• at 2 months of age

integument
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory