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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc12a6tm1Garo
targeted mutation 1, Guy A Rouleau
MGI:5318538
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc12a6tm1Garo/Slc12a6tm1Garo B6.129-Slc12a6tm1Garo MGI:5318540
cn2
Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
involves: 129 * C57BL/6 * CBA MGI:5318542


Genotype
MGI:5318540
hm1
Allelic
Composition
Slc12a6tm1Garo/Slc12a6tm1Garo
Genetic
Background
B6.129-Slc12a6tm1Garo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a6tm1Garo mutation (1 available); any Slc12a6 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile with no signs of neuropathy or motor weakness




Genotype
MGI:5318542
cn2
Allelic
Composition
Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a6tm1Garo mutation (1 available); any Slc12a6 mutation (86 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• unable to successfully breed

nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age
• at 2 months of age
• hypoplastic with a small but significant decrease in length
• axon swelling in sciatic nerves
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
• in sciatic nerves
• hypomyelination in sciatic nerves

behavior/neurological
• by 3-4 weeks of age
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size/body
• at 2 months of age

integument
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory