Mouse Genome Informatics
hm1
     Slc12a6tm1Garo/Slc12a6tm1Garo
B6.129-Slc12a6tm1Garo
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:183239 )
• viable and fertile with no signs of neuropathy or motor weakness


Mouse Genome Informatics
cn2
     Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
involves: 129 * C57BL/6 * CBA
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
reproductive system
infertility ( J:183239 )
• unable to successfully breed

nervous system
abnormal nervous system morphology ( J:183239 )
• progressive peripheral neuropathy starting at 3-4 weeks of age
increased brain weight ( J:183239 )
• at 2 months of age
decreased corpus callosum size ( J:183239 )
• hypoplastic with a small but significant decrease in length
abnormal axon morphology ( J:183239 )
• axon swelling in sciatic nerves
abnormal sciatic nerve morphology ( J:183239 )
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
demyelination ( J:183239 )
• hypomyelination in sciatic nerves
axon degeneration ( J:183239 )
• in sciatic nerves

behavior/neurological
limb grasping ( J:183239 )
• by 3-4 weeks of age
abnormal locomotor behavior ( J:183239 )
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
hyperactivity ( J:183239 )
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
decreased chemical nociceptive threshold ( J:183239 )
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size
decreased body weight ( J:183239 )
• at 2 months of age

integument
decreased chemical nociceptive threshold ( J:183239 )
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain