Phenotypes associated with this allele

• Allele Symbol: Pdilt^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:5316367
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdilt^tm1Osb/Pdilt^tm1Osb	involves: 129S2/SvPas	MGI:5316368

Genotype
MGI:5316368

hm1

• Allelic Composition: Pdilt^tm1Osb/Pdilt^tm1Osb
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:182133 )

♂N • normal spermatogenesis

♂N • normal sperm although ADAM3 absent from the surface of mature sperm

♂N • capacitated sperm deposited directly in oviduct are able to fertilize eggs, requires presence of cumulus cells

male infertility ( J:182133 )

♂ • males infertile when mated to wild-type females despite normal mating behavior, sperm ejaculation, and vaginal plug formation

♂ • sperm restricted to uterus of female reproductive tract

abnormal sperm physiology ( J:182133 )

♂ • ability of sperm to fertilize eggs requires the presence of cumulus cells

impaired sperm migration in female genital tract ( J:182133 )

♂ • impaired sperm migration from the uterus into the oviduct; sperm are not observed in the uterotubal junction

cellular

impaired sperm migration in female genital tract ( J:182133 )

♂ • impaired sperm migration from the uterus into the oviduct; sperm are not observed in the uterotubal junction

behavior/neurological

behavior/neurological phenotype ( J:182133 )

♂N • male reproductive behavior is normal