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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcb8tm1Hard
targeted mutation 1, Hossein Ardehali
MGI:5315860
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Abcb8tm1Hard/Abcb8tm1Hard
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
involves: FVB MGI:5315861


Genotype
MGI:5315861
cn1
Allelic
Composition
Abcb8tm1Hard/Abcb8tm1Hard
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (2 available); any A1cf mutation (21 available)
Abcb8tm1Hard mutation (0 available); any Abcb8 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• subcellular disorganization, with accumulation of vacuoles, mitochondria showing diversity in size, profoundly disrupted alignment, and a rounder and more densely packed appearance after tamoxifen treatment
• loss of mitochondrial cristae and smaller average mitochondria size after tamoxifen treatment
• elevated mitochondrial iron content but not heme levels 4 weeks after tamoxifen treatment
• distorted and wavy myofiber architecture 4 weeks after tamoxifen treatment
• mitochondrial deformities accompanied by electron-dense material are present after tamoxifen treatment
• 8 weeks after tamoxifen treatment
• increased left ventricular diastolic diameter at 8 weeks after tamoxifen treatment
• 8 weeks after tamoxifen treatment
• elevated lipid peroxidation and reactive oxygen species after tamoxifen treatment
• as early as 4 weeks after tamoxifen treatment
• reduced heart pump function as measured by fractional shortening and ejection fraction 4 and 8 weeks after tamoxifen treatment
• decreased strength of contraction (dP/dtmax) at 8 weeks after tamoxifen treatment
• decreased relaxation (dP/dtmin) at 8 weeks after tamoxifen treatment
• lower end systolic pressure at 8 weeks after tamoxifen treatment
• mild after tamoxifen treatment

homeostasis/metabolism
• elevated mitochondrial iron content but not heme levels 4 weeks after tamoxifen treatment

muscle
• distorted and wavy myofiber architecture 4 weeks after tamoxifen treatment
• mitochondrial deformities accompanied by electron-dense material are present after tamoxifen treatment
• reduced heart pump function as measured by fractional shortening and ejection fraction 4 and 8 weeks after tamoxifen treatment
• decreased strength of contraction (dP/dtmax) at 8 weeks after tamoxifen treatment
• decreased relaxation (dP/dtmin) at 8 weeks after tamoxifen treatment
• mild after tamoxifen treatment





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory