Phenotypes associated with this allele

• Allele Symbol: Wnt7a^px-2J
• Allele Name: postaxial hemimelia 2 Jackson
• Allele ID: MGI:5315309
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt7a^px-2J/Wnt7a^px-2J	B6;C3Fe-Wnt7a^px-2J/GrsrJ	MGI:5440925
hm2	Wnt7a^px-2J/Wnt7a^px-2J	involves: C3HeB/FeJ * C57BL/6J * CAST/EiJ	MGI:5440974

Genotype
MGI:5440925

hm1

• Allelic Composition: Wnt7a^px-2J/Wnt7a^px-2J
• Genetic Background: B6;C3Fe-Wnt7a^px-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:188478 )

• digits on the front paws can be twisted, swollen, fused or missing

fused phalanges ( J:188478 )

oligodactyly ( J:188478 )

abnormal forelimb morphology ( J:188478 )

• the front legs are set at odd angles to the trunk, in a manner suggestive of flippers, and are usually shorter than normal

abnormal humerus morphology ( J:188478 )

• the humerus is generally shorter than normal

short humerus ( J:188478 )

hemimelia ( J:188478 )

skeleton

fused phalanges ( J:188478 )

abnormal humerus morphology ( J:188478 )

• the humerus is generally shorter than normal

short humerus ( J:188478 )

behavior/neurological

limb grasping ( J:188478 )

• when raised by the tail homozygotes clasp their hindlegs together rather than splay them

abnormal gait ( J:188478 )

• Due to the shortened, twisted front legs homozygotes have a slightly side-to-side gait

reproductive system

female infertility ( J:188478 )

♀

male infertility ( J:188478 )

♂

integument

abnormal skin appearance ( J:188478 )

• black bumps are found on the skin of the upper surface of the paws

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:188478 )

N • hearing was assessed by auditory brainsetm response is normal at 1, 3, and 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fuhrmann syndrome		DOID:0090067	OMIM:228930	J:188478

Genotype
MGI:5440974

hm2

• Allelic Composition: Wnt7a^px-2J/Wnt7a^px-2J
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J * CAST/EiJ

mortality/aging

prenatal lethality, incomplete penetrance ( J:188478 )

• Background Sensitivity: Although on a B6;C3Fe segregating background the number of mutants produced from a heterozygous intercross fits Mendelian expectation, when outcrossed to CAST/EiJ then intercrossed fewer than 9% of the offspring from heterozygous intercrosses are mutant when classified at 1 week of age