Mouse Genome Informatics
tg1
    Tg(CRYBB1-CRYGC*)#Jfhe/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae
• the fiber cell migration and elongation patter is defective at the equatorial region
• mutants exhibit nuclear cataracts of varying severities

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 2, Multiple Types; CTRCT2 604307 J:181433