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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CRYBB1-CRYGC*)#Jfhe
transgene insertion, J Fielding Hejtmancik
MGI:5313507
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(CRYBB1-CRYGC*)#Jfhe/? involves: FVB/N MGI:5313510


Genotype
MGI:5313510
tg1
Allelic
Composition
Tg(CRYBB1-CRYGC*)#Jfhe/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells (J:181433)
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae (J:181433)
• the fiber cell migration and elongation patter is defective at the equatorial region (J:181433)
• the fiber cell migration and elongation patter is defective at the equatorial region (J:181433)
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells (J:181433)
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae (J:181433)
• mutants exhibit nuclear cataracts of varying severities (J:181433)
• mutants exhibit nuclear cataracts of varying severities (J:181433)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 2, Multiple Types; CTRCT2 604307 J:181433





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory