Phenotypes associated with this allele

• Allele Symbol: Tg(Avil-icre/ERT2)AJwo
• Allele Name: transgene insertion A, John N Wood
• Allele ID: MGI:5312922
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kcns1^tm1.1Kcl/Kcns1^tm1.1Kcl Tg(Avil-icre/ERT2)AJwo/0	involves: 129S7/SvEvBrd * C57BL/6J	MGI:6357188
cn2	Adam23^tm1.1Mejr/Adam23^tm1.1Mejr Tg(Avil-icre/ERT2)AJwo/0	Not Specified	MGI:7444422
tg3	Tg(Avil-icre/ERT2)AJwo/0	Not Specified	MGI:5312934

Genotype
MGI:6357188

cn1

• Allelic Composition: Kcns1^tm1.1Kcl/Kcns1^tm1.1Kcl; Tg(Avil-icre/ERT2)AJwo/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced coordination ( J:276188 )

• on a rotarod in tamoxifen-treated mice

abnormal mechanical nociception ( J:276188 )

• reduced threshold in tamoxifen-treated mice; more pronounced in female mice

• reduced threshold following neuropathic pain induced by nerve injury in tamoxifen-treated mice

• however, hot or cold thermal nociception is normal

hyperalgesia ( J:276188 )

• in response to mechanical pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice

hyperresponsive to tactile stimuli ( J:276188 )

• reduced threshold in tamoxifen-treated mice; more pronounced in female mice

• however, hot or cold thermal nociception is normal

decreased thermal nociceptive threshold ( J:276188 )

• to innocuous and noxious cold temperatures pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice

• however, hot thermal nociception in a neuropathic pain model is normal

Genotype
MGI:7444422

cn2

• Allelic Composition: Adam23^tm1.1Mejr/Adam23^tm1.1Mejr; Tg(Avil-icre/ERT2)AJwo/0
• Genetic Background: Not Specified

nervous system

abnormal neuron morphology ( J:333962 )

• Kv1 channel complex protein disappear form the juxtaparanodal membrane between 10- and 29-weeks post-tamoxifen treatment

Genotype
MGI:5312934

tg3

• Allelic Composition: Tg(Avil-icre/ERT2)AJwo/0
• Genetic Background: Not Specified

behavior/neurological

behavior/neurological phenotype ( J:181671 )

N • motor function in tamoxifen-treated mice is not significantly different from controls

N • acute and imflammatory behavior in tamoxifen-treated mice is not different from controls