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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arl6tm2Vcs
targeted mutation 2, Val C Sheffield
MGI:5310744
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arl6tm2Vcs/Arl6tm2Vcs involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5310750


Genotype
MGI:5310750
hm1
Allelic
Composition
Arl6tm2Vcs/Arl6tm2Vcs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl6tm2Vcs mutation (4 available); any Arl6 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• inner nuclear and ganglion cell layers of retina are normal

nervous system
• ependymal cilia display a chaotic beating pattern
• reduced number and misshapen ependymal cell cilia
• paddle shaped cilia with terminal dilatations seen in culture
• severe hydrocephalus
• corpus striatum reduced in size
• increased renal sympathetic nerve activity

reproductive system
• sperm in seminiferous tubules of 4 month old homozygotes lack flagella
• males fail to produce offspring

craniofacial
• splaying of cranial sutures

cellular
N
• primary cilia are normal
• reduced number and misshapen ependymal cell cilia
• paddle shaped cilia with terminal dilatations seen in culture
• sperm in seminiferous tubules of 4 month old homozygotes lack flagella
• ependymal cilia display a chaotic beating pattern

adipose tissue
• increased fat mass but body weight is normal

cardiovascular system
• increased 24 hour arterial blood pressure

behavior/neurological
N
• mice are not hyperphagic

skeleton
• splaying of cranial sutures





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory