Mouse Genome Informatics
ht1
    Mecp2tm1.1Joez/Mecp2+
B6.129-Mecp2tm1.1Joez
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• mice exhibit normal survival (J:181311)

behavior/neurological
• mice exhibit RTT-like symptoms after 17 weeks of age (J:181311)
• at 20, but not 12, weeks of age (J:181311)

growth/size/body


Mouse Genome Informatics
cx2
    Mecp2tm1.1Joez/Y
Tg(Thy1-EGFP)#Jrs/0

involves: 129 * C57BL/6 * C57BL/6J * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at P30 and P90, hippocampal CA1 pyramidal neurons exhibit decreased soma size compared with control cells (J:181311)


Mouse Genome Informatics
ot3
    Mecp2tm1.1Joez/Y
B6.129-Mecp2tm1.1Joez
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 50% of mice die by 16 weeks of age (J:181311)

behavior/neurological
• mice exhibit RTT-like symptoms after 5 weeks of age (J:181311)
• in an elevated zero maze (J:181311)
• impaired motor learning on a rotarod (J:181311)
• at 13 weeks of age (J:181311)
• on a rotarod (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
(J:181311)
• at 11, but not 3, weeks of age (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
• with splaying hind limbs upon movement (J:181311)
• occasionally after 5 weeks of age (J:181311)

nervous system
• occasionally after 5 weeks of age (J:181311)
• at P30 and P90 (J:181311)
• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice (J:181311)
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice (J:181311)
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice (J:181311)
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice (J:181311)
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice (J:181311)
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice (J:181311)
• however, mice exhibit normal power and event-related potential at P30 (J:181311)

growth/size/body
• between 4 and 8 weeks of age (J:181311)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:181311