• mice exhibit normal survival

• mice exhibit RTT-like symptoms after 17 weeks of age

• at 20, but not 12, weeks of age

• at P30 and P90, hippocampal CA1 pyramidal neurons exhibit decreased soma size compared with control cells

• 50% of mice die by 16 weeks of age

• mice exhibit RTT-like symptoms after 5 weeks of age

• in an elevated zero maze

• impaired motor learning on a rotarod

• at 13 weeks of age

• on a rotarod

• not as severe as in Mecp2^tm1.1Jae hemizygotes

• at 11, but not 3, weeks of age

• not as severe as in Mecp2^tm1.1Jae hemizygotes

• with splaying hind limbs upon movement

• occasionally after 5 weeks of age

• occasionally after 5 weeks of age

• at P30 and P90

• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice

• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice

• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice

• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice

• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice

• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice

• however, mice exhibit normal power and event-related potential at P30

• between 4 and 8 weeks of age