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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecp2tm1.1Joez
targeted mutation 1.1, Zhaolan Zhou
MGI:5310727
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mecp2tm1.1Joez/Mecp2+ B6.129-Mecp2tm1.1Joez MGI:5310738
cx2
Mecp2tm1.1Joez/Y
Tg(Thy1-EGFP)#Jrs/0
involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5310737
ot3
Mecp2tm1.1Joez/Y B6.129-Mecp2tm1.1Joez MGI:5310735


Genotype
MGI:5310738
ht1
Allelic
Composition
Mecp2tm1.1Joez/Mecp2+
Genetic
Background
B6.129-Mecp2tm1.1Joez
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Joez mutation (1 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival

behavior/neurological
• mice exhibit RTT-like symptoms after 17 weeks of age
• at 20, but not 12, weeks of age

growth/size/body




Genotype
MGI:5310737
cx2
Allelic
Composition
Mecp2tm1.1Joez/Y
Tg(Thy1-EGFP)#Jrs/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Joez mutation (1 available); any Mecp2 mutation (25 available)
Tg(Thy1-EGFP)#Jrs mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P30 and P90, hippocampal CA1 pyramidal neurons exhibit decreased soma size compared with control cells




Genotype
MGI:5310735
ot3
Allelic
Composition
Mecp2tm1.1Joez/Y
Genetic
Background
B6.129-Mecp2tm1.1Joez
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Joez mutation (1 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die by 16 weeks of age

behavior/neurological
• mice exhibit RTT-like symptoms after 5 weeks of age
• impaired motor learning on a rotarod
• in an elevated zero maze
• at 13 weeks of age
• on a rotarod
• not as severe as in Mecp2tm1.1Jae hemizygotes
• at 11, but not 3, weeks of age
• not as severe as in Mecp2tm1.1Jae hemizygotes
• with splaying hind limbs upon movement
• occasionally after 5 weeks of age

nervous system
• occasionally after 5 weeks of age
• at P30 and P90
• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice
• however, mice exhibit normal power and event-related potential at P30

growth/size/body
• between 4 and 8 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:181311





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory