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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Asltm1Brle
targeted mutation 1, Brendan Lee
MGI:5308970
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Asltm1Brle/Asltm1Brle involves: 129S7/SvEvBrd MGI:5308984
cx2
Asltm1Brle/Asl+
Nos3tm1Weo/Nos3+
involves: 129S7/SvEvBrd MGI:5308985


Genotype
MGI:5308984
hm1
Allelic
Composition
Asltm1Brle/Asltm1Brle
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asltm1Brle mutation (1 available); any Asl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within the first 3 to 4 weeks due to multiorgan failure (J:180208)
• however, mice treated with sodium nitrite, arginine, arginine and sodium benzoate, or all three therapies exhibit improved survival (J:180208)
• mice die within the first 3 to 4 weeks due to multiorgan failure (J:180208)
• however, mice treated with sodium nitrite, arginine, arginine and sodium benzoate, or all three therapies exhibit improved survival (J:180208)

immune system
• thin (J:180208)
• thin (J:180208)
• in the spleen and thymus (J:180208)
• in the spleen and thymus (J:180208)
• in the thymus cortex (J:180208)
• in the thymus cortex (J:180208)

homeostasis/metabolism
• mice exhibit increased plasma citrulline and decreased arginine levels compared with wild-type mice (J:180208)
• mice exhibit increased plasma citrulline and decreased arginine levels compared with wild-type mice (J:180208)
• decreased nitrosylation in the liver and heart (J:180208)
• decreased nitrosylation in the liver and heart (J:180208)

cardiovascular system
• atrophic in the myocardium (J:180208)
• atrophic in the myocardium (J:180208)
• impaired in response to acetylcholine treatment (J:180208)
• however, relaxation in response to sodium nitroprusside is normal (J:180208)
• impaired in response to acetylcholine treatment (J:180208)
• however, relaxation in response to sodium nitroprusside is normal (J:180208)
• however, mice treated with sodium nitrite, arginine and sodium benzoate exhibit normalizes blood pressure (J:180208)
• however, mice treated with sodium nitrite, arginine and sodium benzoate exhibit normalizes blood pressure (J:180208)
• however, mice treated with sodium nitrite, arginine and sodium benzoate exhibit normalizes blood pressure (J:180208)
• however, mice treated with sodium nitrite, arginine and sodium benzoate exhibit normalizes blood pressure (J:180208)

integument
• abnormal hair patterning by 2 weeks of age (J:180208)
• abnormal hair patterning by 2 weeks of age (J:180208)
• small and disorganized (J:180208)
• small and disorganized (J:180208)
• atrophic (J:180208)
• atrophic (J:180208)

growth/size/body
• at 3 and 4 weeks of age (J:180208)
• however, mice treated with sodium nitrite or sodium nitrite, arginine and sodium benzoate exhibit increased weight (J:180208)
• at 3 and 4 weeks of age (J:180208)
• however, mice treated with sodium nitrite or sodium nitrite, arginine and sodium benzoate exhibit increased weight (J:180208)
• by 2 weeks of age (J:180208)
• by 2 weeks of age (J:180208)

renal/urinary system
• smaller than in wild-type mice (J:180208)
• smaller than in wild-type mice (J:180208)

muscle
• atrophic in the myocardium (J:180208)
• atrophic in the myocardium (J:180208)
• impaired in response to acetylcholine treatment (J:180208)
• however, relaxation in response to sodium nitroprusside is normal (J:180208)
• impaired in response to acetylcholine treatment (J:180208)
• however, relaxation in response to sodium nitroprusside is normal (J:180208)

hematopoietic system
• thin (J:180208)
• thin (J:180208)
• mice exhibit more numerous acanthocytes and fewer spherocytes than in wild-type mice (J:180208)
• mice exhibit more numerous acanthocytes and fewer spherocytes than in wild-type mice (J:180208)
• more numerous acanthocytes than in wild-type mice (J:180208)
• more numerous acanthocytes than in wild-type mice (J:180208)
• in the spleen and thymus (J:180208)
• in the spleen and thymus (J:180208)
• in the thymus cortex (J:180208)
• in the thymus cortex (J:180208)

endocrine/exocrine glands
• thin (J:180208)
• thin (J:180208)

Mouse Models of Human Disease
OMIM ID Ref(s)
Argininosuccinic Aciduria 207900 J:196817




Genotype
MGI:5308985
cx2
Allelic
Composition
Asltm1Brle/Asl+
Nos3tm1Weo/Nos3+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asltm1Brle mutation (1 available); any Asl mutation (1 available)
Nos3tm1Weo mutation (0 available); any Nos3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• compared with Nos3tm1Weo heterozygotes (J:180208)
• compared with Nos3tm1Weo heterozygotes (J:180208)
• compared with Nos3tm1Weo heterozygotes (J:180208)
• compared with Nos3tm1Weo heterozygotes (J:180208)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory