Phenotypes associated with this allele

• Allele Symbol: Cd207^{tm2.1(cre)Bjec}
• Allele Name: targeted mutation 2.1, Bjorn Clausen
• Allele ID: MGI:5308064
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cd207^tm2.1(cre)Bjec/Cd207^+	B6.Cg-CD207^tm2.1(cre)Bjec	MGI:5308084
cn2	Braf^tm1Mmcm/Braf^tm1Mmcm Cd207^tm2.1(cre)Bjec/Cd207^+	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:6192274
cn3	Cd207^tm2.1(cre)Bjec/Cd207^+ Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl	involves: 129S4/SvJaeSor * C57BL/6	MGI:5308087

Genotype
MGI:5308084

ht1

• Allelic Composition: Cd207^{tm2.1(cre)Bjec}/Cd207⁺
• Genetic Background: B6.Cg-CD207^{tm2.1(cre)Bjec}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:179630 )

N • after FITC painting (hapten challenge) to dorsal ear skin, the ear-swelling response is not different from wild-type animals (24 and 48 hours after application); this indicates that there is no alteration in Cd207-positive skin dendritic cell (DC) migration to skin-draining lymph nodes (sLN) or DC function in mutants

Genotype
MGI:6192274

cn2

• Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm; Cd207^{tm2.1(cre)Bjec}/Cd207⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

hematopoietic system

increased dendritic cell number ( J:211690 )

• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver

• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers

immune system

increased dendritic cell number ( J:211690 )

• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver

• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers

liver inflammation ( J:211690 )

• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age

lung inflammation ( J:211690 )

• by 20 weeks of age, all mice show small lesions in the lung

liver/biliary system

liver inflammation ( J:211690 )

• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age

respiratory system

lung inflammation ( J:211690 )

• by 20 weeks of age, all mice show small lesions in the lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Langerhans-cell histiocytosis		DOID:2571	OMIM:246400 OMIM:604856	J:211690

Genotype
MGI:5308087

cn3

• Allelic Composition: Cd207^{tm2.1(cre)Bjec}/Cd207⁺; Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

immune system

decreased dendritic cell number ( J:179630 )

• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis

abnormal type IV hypersensitivity reaction ( J:179630 )

• contact hypersensitivity assessed by ear swelling is attenuated at 24 hours after hapten challenge relative to wild-type controls

hematopoietic system

decreased dendritic cell number ( J:179630 )

• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis