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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ED-L2-IL1RN/IL1B)#Tcw
transgene insertion, Timothy C Wang
MGI:5308012
Summary 3 genotypes


Genotype
MGI:5308014
cx1
Allelic
Composition
Il6tm1Kopf/Il6tm1Kopf
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background
B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (37 available)
Tg(ED-L2-IL1RN/IL1B)#Tcw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• absence of Il6 expression completely abolishes the metaplastic and dysplastic phenotypes seen in transgenic mice expressing Il6
• minor inflammatory response

immune system
• minor inflammatory response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT Barrett's esophagus DOID:9206 OMIM:614266
J:180282




Genotype
MGI:5308015
cx2
Allelic
Composition
Il6tm1Kopf/Il6+
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background
B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (37 available)
Tg(ED-L2-IL1RN/IL1B)#Tcw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• reduced of Il6 expression completely decreases metaplasia and abolishes dysplasia

immune system




Genotype
MGI:5308013
tg3
Allelic
Composition
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background
B6.Cg-Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• at 6 months of age profound epithelial hyperplasia is seen in the squamocolumnar junction
• at 12-15 months of age, 90% of mice display severe columnar metaplasia with mucus producing cells in the squamocolumnar junction
• treatment with 0.2% deoxycholate accelerates the development of Barrett-like metaplasia in the squamocolumnar junction
• at 20-22 months of age about 20% of mice develop high-grade dysplasia or intramucosal esophageal adenocarcinoma
• at 20-22 months of age lesions are grossly visible within the distal end of the esophagus
• mutant esophagi show circumferential erythema and edema with inflammatory exudates compared to the normal esophagus and changes are made more severe by treatment with 0.2% deoxycholate
• expansion of gastric cardia progenitor cells in the esophagus over time
• markedly thickened
• markedly thickened with a mix of acute and chronic inflammatory infiltrate
• markedly thickened forestomach with a mix of acute and chronic inflammatory infiltrate
• increase in proliferation in the esophageal basal compartment
• mix of acute and chronic inflammatory infiltrate
• treatment with 0.2% deoxycholate induced more severe esophagitis with inflammatory infiltrates in mutant mice compared to wild-type controls

neoplasm
• mice treated with 0.2% deoxycholate and N-methyl-N-nitrosourea show increased esophageal tumor development compared to wild-type controls
• at 20-22 months of age about 20% of mice develop high-grade dysplasia or intramucosal esophageal adenocarcinoma
• during the stepwise progression to cancer there is a gradual increase in alpha SMA+ stromal myofibroblasts and increasing stroma global hypomethylation

immune system
• elevated IL6 in the tongue, esophagus, and forestomach but not in the stomach
• mix of acute and chronic inflammatory infiltrate in the forestomach
• at 6 months of age moderate inflammation is seen in the squamocolumnar junction
• mix of acute and chronic inflammatory infiltrate
• treatment with 0.2% deoxycholate induced more severe esophagitis with inflammatory infiltrates in mutant mice compared to wild-type controls

homeostasis/metabolism
• elevated IL6 in the tongue, esophagus, and forestomach but not in the stomach
• mice treated with 0.2% deoxycholate and N-methyl-N-nitrosourea show increased esophageal tumor development compared to wild-type controls

growth/size/body
• markedly thickened
• at 20-22 months, associated with gross esophageal lesions

hematopoietic system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Barrett's esophagus DOID:9206 OMIM:614266
J:180282
esophageal cancer DOID:5041 OMIM:133239
J:180282





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory